Virtual Lesions Examining with Reversible Deactivation 1st Edition by Stephen Lomber, Ralf Galuske ISBN 978-0198508939 019850893X

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ISBN 10:  019850893X

ISBN 13: 978-0198508939

Author: Stephen Lomber, Ralf Galuske

The study of brain lesions and their impact on cognition and behavior has been the dominant tool used to examine the complex function of the brain for the last three centuries. By testing neuropsychological deficits that correlate with a lesion in a particular part of the brain, it is possible to hypothesise about the role and cognitive function of that individual brain area. Over the past several decades, the rapid development and implementation of many new technologies to visualize brain activity has greatly augmented our understanding of brain function. However, even now there are many experimental questions that are difficult, if not impossible to answer in any way other than lesion techniques. Such studies though are not without their own challenges to overcome such as lesion-induced neuroplasticity, widespread degenerative changes, and the permanent nature of a lesion. Recent developments in different fields of neuroscience have provided tools to overcome many of the problems related to conventional lesion techniques and have succeeded to synthesizing these new approaches with a variety of new techniques to visualize brain activity on the level of individual neurons as well as on the level of cognitive performance.

Table of contents: 

Part I: Exploring Neural Circuits

1.Intracortical Mechanisms Underlying Orientation and Direction Selectivity – J.M. Crook, Z.F. Kisvárday, and U.T. Eysel

2.Contributions of Ascending Thalamic and Local Intracortical Connections to Visual Cortical Function – V. Dragoi, C. Rivadulla, and M. Sur

3.In Search of the Role of Extrageniculate Corticothalamic Loops in Visual Processing Using Reversible Deactivation Techniques – C. Casanova

4.Cortical Modulation of Auditory Processing in the Thalamus – A.E.P. Villa

5.Deactivation of Feedforward and Feedback Pathways in the Visual Cortex of the Monkey – P. Girard and J. Bullier

6.Examining the Basis of Neural Plasticity Using Chronic Pharmacologic Applications – R.A.W. Galuske, Dae-Shik Kim, and K.E. Schmidt

Part II: Investigating Behavior in Animals
7. The Use of Cooling Deactivation to Reveal the Neural Basis of Lesion-Induced Plasticity in the Developing and Mature Cerebral Cortex – B.R. Payne and S.G. Lomber
8. Dissecting the Organization of Cortical and Subcortical Circuits for Skilled Limb Movement Control in Development and Maturity with Reversible Inactivation – J.H. Martin and C. Ghez
9. Cerebral Control of Eye Movements – M.A. Segraves
10. Reversible Impairment of an Auditory-Visual Association Task – G. Sierra-Paredes and J.M. Fuster

Part III: Probing the Human Brain
11. Case Studies in Virtual Neuropsychology: Reversible Lesions and Magnetic Brain Stimulation – V. Walsh and A. Pascual-Leone
12. Metamodal Cortical Processing in the Occipital Cortex of Blind and Sighted Subjects – A. Pascual-Leone and R.H. Hamilton
13. Excitability of Human Visual Cortex Examined with Transcranial Magnetic Stimulation – B. Boroojerdi and L.G. Cohen
14. Negative Phenomena Induced by TMS of Human Primary Motor Cortex – U. Ziemann

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Tags: Stephen Lomber, Ralf Galuske, Virtual Lesions Examining, Cortical Function