Trends in Drug Research III First Edition by Henk Van Der Goot ISBN 0444540040 978-0444540041

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ISBN 10:  0444540040 

ISBN 13: 978-0444540041

Author: Henk Van Der Goot

The tradition of setting new trends in medicinal chemistry continued at the 13th Symposium where topics included chemical and biological diversity, new paradigms in drug action, and new insights in receptor mechanisms. Other topics of great interest discussed, and included in these proceedings, are the discoveries in green chemistry, the interface between organic synthesis and biosynthesis, the growing problem of resistant micro-organisms and the possibilities to identify new, and better, antibiotics. And finally, in recent developments, the discovery of small molecules with insulin sensitizing properties.

Table of contents: 

1 A. Hogner, J.S. Kastrup, J. Greenwood, S.B. Vogensen, E.H. Moller, T.B. Stensbøl, J. Egebjerg and P. Krogsgaard-Larsen
Towards rational design of AMPA receptor ligands: an integrated medicinal, computational, biostructural and molecular pharmacological approach

2 C.C.A. van Boeckel
From heparin to synthetic antithrombotics. The pentasaccharide story and follow-up

3 A. Bruggink
A new future for synthesis?

4 M.T. Reetz
Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals

5 R. Schoevaart and A.P.G. Kieboom
At the interface of organic synthesis and biosynthesis

6 R.E. Hubbart
What can structure tell us about function in the estrogen receptors?

7 M. Kouwijzer and J. Mestres
Molecular docking and dynamics simulations in the ligand binding domain of steroid hormone receptors

8 S. Kliewer
Peroxisome proliferator-activated receptors and reverse endocrinology

9 A.J.R. Heck and C.S. Maier
Biomolecular mass spectrometry related to drug research

10 P. Angeli and G. Gaviraghi
Chemical and biological diversity in drug discovery

11 J. Gomeza, M. Yamada, A. Duttaroy, W. Zhang, R. Makita, T. Miyakawa, J. Crawley, L. Zhang, H. Shannon, F.P. City Master, C.C. Felder, C. Deng and J. Wess
Muscarine acetylcholine receptor knockout mice: phenotypical analysis and clinical implications

12 P.F. Zaratin, A. Quattrini, S. Previtali, G. Hervieu and M.A. Divider
Changes in expression of the orphan G-protein coupled receptor GPR7 in human painful peripheral neuropathies

13 V.J. Gillet and P. Willett
Computational methods for the analysis of molecular diversity

14 D. Langley
Enhancing drug discovery by acquisition of chemical diversity

15 P. Seneci
Chemical diversity as a driving force to design and put in practice synthetic strategies leading to combinatorial libraries for lead discovery and lead optimization

16 H. Just, E. Stefan, C. Czupalla, B. Nürnberg, Chr. Nanoff and M. Freissmuth
Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signalling

17 Ph.G. Strange
Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D2 dopamine receptor

18 K.E.O. Åkerman, J. Näsman, T. Holmqvist and J.P. Kukkonen
Agonist channeling of a2-adrenoceptor function

19 D. Golemi, L. Maveyraud, J. Haddad, W. Lee, A. Ishiwata, K. Miyashita, L. Mourey, S. Vakulenko, L. Kotra, J. Samama, and S. Mobashery
Antibacterials as wonder drugs and how their effectiveness is being compromised

20 E.P. Greenberg
Pseudomonas aeruginosa quorum sensing: a target for antipathogenic drug discovery

21 I. Chopra, L. Hesse and A. O’Neill
Discovery and development of new anti-bacterial drugs

22 B.B. Zhang
Discovery of small molecule insulin mimetics as potential novel antidiabetic agents

23 L.M. Furness
Expression databases for pharmaceutical lead optimisation

24 R.G. Pertwee
New developments in the pharmacology of cannabinoids

25 Author index
26 Subject index

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Tags: Henk Van Der Goot, Trends in Drug, Research III