Translational Animal Models in Drug Discovery and Development 1st Edition by Xinkang Wang ISBN 1608055914 978-1608055913

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Product details: 

ISBN 10: 1608055914

ISBN 13:  978-1608055913

Author:  Xinkang Wang 
Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since considerable differences in variables exist between animal models and human models (such as genetics, physiology, anatomy, gene expression, heterogeneity of disease conditions, etc.), not all the preclinical models are able to represent the pathophysiological conditions in human diseases. Therefore, partly due to the lack of congruency between animal and human disease models, several proposed therapeutic agents in the past decades have been demonstrated to be effective in preclinical models but failed in clinical studies. This book focuses on animal models of diseases from a translational perspective and highlights the key advantages and limitations of each model described to facilitate drug discovery and development. A unique feature of the volume is that it contains a selection of details disease models in various therapeutic niches with significant unmet medical needs, including inflammation, neurological diseases, cardiovascular and metabolic diseases, and oncology. This book is, therefore, of considerable value to researchers and clinicians involved in drug discovery and development as well as pathology.

Table of contents: 

1. Foreword

2. Preface

3. List of Contributors

4. Animal Models of Atherosclerosis and Spontaneous Plaque Rupture

5. Experimental Models of Heart Failure: Translational Investigation of Cardiac Drug Safety

6. Animal Models of Ischemic Stroke: Issues in Translational Congruency

7. Mouse Models of Coagulation Factor Deficiencies for Translational Research

8. Xenograft Models of the Normal and Malignant Human Breast

9. BALB-neuT Female Mice as a Dynamic Model of Mammary Cancer

10. Modeling Human Asthma in Animals

11. Cigarette Smoke-Induced Translational Animal Models of Chronic Obstructive Lung Disease

12. Mouse Models of Inflammatory Bowel Disease: Mechanistic Insight into Current and Future Therapeutics

13. In Vivo Veritas: Preclinical Models of Human Arthritic Disease in Non-Human Primates

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Tags: Xinkang Wang, Translational Animal, Drug Discovery