Transgenic and Knockout Models of Neuropsychiatric Disorders 1st Edition by Gene Fisch, Jonathan Flint ISBN 1588295071 978-1588295071

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Product details: 

ISBN 10:  1588295071

ISBN 13:   978-1588295071

Author: Gene S. Fisch, Jonathan Flint
In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Table of contents: 

I Introduction and Overview

1. Transgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and Assessment
   Gene S. Fisch

2. Transgenic Mouse Models and Human Psychiatric Disease
   Jonathan Flint

3. Transgenic and Knockout Mouse Models: The Problem of Language
   Linda J. Hayes and Diana Delgado

4. If Only They Could Talk: Genetic Mouse Models for Psychiatric Disorders
   Trevor Humby and Lawrence Wilkinson

II Transgenic and Knockout Models of Neurocognitive Dysfunction

5. Spinocerebellar Ataxia Type 1: Lessons From Modeling a Movement Disease in Mice
   Harry T. Orr

6. Mouse Models of Hereditary Mental Retardation
   Hans Welzl, Patrizia D’Adamo, David P. Wolfer, and Hans-Peter Lipp

7. How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?
   Simon E. Fisher

8. Animal Models of Autism: Proposed Behavioral Paradigms and Biological Studies
   Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon

III Transgenic and Knockout Models of Neuropsychiatric Dysfunction

9. Genetic Mouse Models of Psychiatric Disorders: Advantages, Limitations, and Challenges
   Joseph A. Gogos and Maria Karayiorgou

10. Animal Models of Psychosis
    Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller, and John Mastropaolo

11. Animal Models of Anxiety: The Ethological Perspective
    Robert Gerlai, Robert Blanchard, and Caroline Blanchard

12. Modeling Human Anxiety and Depression in Mutant Mice
    Andrew Holmes and John F. Cryan

13. Mutant Mouse Models of Bipolar Disorder: Are There Any?
    Anneloes Dirks, Lucianne Groenink, and Berend Olivier

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Gene Fisch,Jonathan Flint,Transgenic and Knockout,Models of Neuropsychiatric