Transforming Growth Factor Beta in Cancer Therapy Volume II Cancer Treatment and Therapy Cancer Drug Discovery and Development 1st Edition by Sonia Jakowlew, Heldin ISBN ‎ 978-1617377365 ‎ 1617377368

Transforming Growth Factor Beta in Cancer Therapy Volume II Cancer Treatment and Therapy Cancer Drug Discovery and Development 1st Edition by Sonia B. Jakowlew, C.-H. Heldin- Ebook PDF Instant Download/Delivery: ‎ 978-1617377365, 1617377368
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Product details: 

ISBN 10: ‎ ‎ 1617377368

ISBN 13:  978-1617377365

Author:  Sonia B. Jakowlew, C.-H. Heldin 

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim­ ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF-~ has been linked to several diseases. For instance, the effect ofTGF-~ on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF-~ has a very complicated role in cancer that is only beginning to be understood.

Table of contents: 

Volume 1: Basic and Clinical Biology
Focuses on:

TGF-ß signaling in normal physiology

Pathobiology in cancer

Normal vs. tumor biology

Role in inflammation and fibrosis

Volume 2: Cancer Treatment and Therapy
Divided into three parts:

Part I: TGF-ß in Developing and Advanced Cancers
Examines how TGF-ß contributes to cancer progression.

Part II: TGF-ß in Cancer Treatment and Therapy
Explores how TGF-ß is targeted in current therapeutic approaches.

Part III: Inhibitors of TGF-ß Signaling
Investigates the development of therapeutic inhibitors targeting the TGF-ß pathway.

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Tags: Sonia Jakowlew, Heldin, Transforming Growth, Beta in Cancer, Cancer Treatment