Toxicology of the Nose and Upper Airways Target Organ Toxicology Series 1st Edition by John B Morris, Dennis J Shusterman ISBN 142008187X 9781420081879

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Product details:

ISBN 10: 142008187X 

ISBN 13: 9781420081879

Author: John B. Morris, Dennis J. Shusterman 

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume:

• Examines the effect of selected pollutants on the upper airways of both humans and experimental animals—emphasizing mechanistic issues in the process
• Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches
• Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics

This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

Table of contents:

1. Structure & function in the upper airway

2. Functional anatomy of the upper airway in experimental animals

3. Functional anatomy of the upper airway in humans

4. Functional neuroanatomy of the upper airway in experimental animals

5. Functional neuroanatomy of the human upper airway

6. Mucosal enzymology of the upper airway. Dosimetry & Toxicokinetics of Nasal Exposure

7. Upper airway dosimetry of gases, vapors and particulate matter in experimental animals

8. Upper airway dosimetry of gases and vapors in humans

9. Upper airway dosimetry of particulate matter in humans. Functional & Pathologic Responses and Their Measurement

10. Exposure and recording systems in human studies

11. Biomarkers of nasal toxicity in experimental animals

12. Biomarkers of nasal toxicity in humans

13. Nasal reflexes in experimental animals

14. Nasal chemosensory irritation in humans

15. Nasal reflexes in humans

16. Olfactory toxicity in humans and experimental animals

17. Inflammatory conditions of the nose and paranasal sinuses in experimental animals

18. Inflammatory conditions of the nose and paranasal sinuses in humans

19. Chronic tissue changes and carcinogenesis in the upper airway

20. Second hand tobacco smoke exposure in humans

21. Chlorine exposure in humans and experimental animals

22. Hydrogen sulfide exposure in experimental animals

23. Sulfur dioxide exposure in humans

24. Exposure to volatile organic compounds in humans. Risk Assessment and Special Topics

25. Benchmark dose and noncancer risk assessment for the upper airways

26. Physico-chemical modeling of sensory irritation in humans and experimental animals

27. Effect of allergic inflammation on irritant responsiveness in the upper airway

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Tags: John B Morris, Dennis J Shusterman, Toxicology, Nose, Upper Airways, Target Organ, Toxicology Series