Toxicology of the gastrointestinal tract 1st Edition by Shayne Gad 0849327938 9780849327933
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ISBN 10: 0849327938
ISBN 13: 978-0849327933
Author: Shayne C. Gad
Toxicology of the Gastrointestinal Tract focuses on the specifics of the mechanisms and adverse effects of xenobiotic agents and pharmaceuticals on the structure and function of the GI tract. The book focuses on a number of specific areas of intestinal research. Beginning with the well-recognized and major functions of nutrient absorption and its role as a protective barrier, the text elaborates on the expanding body of knowledge that relates to the intestines as a major metabolic and immunologic organ involved in the synthesis and degradation of both natural and foreign substances. It includes an overview of the function and dysfunction of the human absorptive process and the effects of microbial flora on these processes, as well as specific classes of toxicants that target the GI tract. The international panel of contributors presents a critical appraisal of the interactions of chemicals and drugs with the gastrointestinal system and the experimental methods and regions of research on which to focus future efforts.
Providing a complete and multidisciplinary overview of the gastrointestinal system both in health and as it is involved in the toxicity of exogenous agents, Toxicology of the Gastrointestinal Tract brings together the current and growing knowledge of this critical organ system in a single volume.
Toxicology of the gastrointestinal tract 1st Table of contents:
1. Introduction to Gastrointestinal Toxicology
- Overview of Gastrointestinal Anatomy and Physiology
- Mechanisms of Toxicity in the Gastrointestinal System
- Principles of Gastrointestinal Toxicology
2. Absorption of Toxicants in the Gastrointestinal Tract
- Mechanisms of Absorption in the GI Tract
- Factors Influencing Absorption of Toxicants
- Role of the Liver in Absorption and Metabolism
3. Toxicology of the Oral Cavity and Esophagus
- Pathophysiology of Oral Toxicants
- Toxic Effects on the Oral Mucosa and Salivary Glands
- Esophageal Toxicity: Caustic Agents and Esophageal Cancer
4. Toxicology of the Stomach
- Gastric Mucosal Defense Mechanisms
- Acid-Related Disorders and Toxicant-Induced Gastritis
- Drugs and Chemicals Toxic to the Stomach
- Alcohol and Gastric Toxicity
5. Toxicology of the Small Intestine
- Intestinal Absorption of Toxicants
- Mechanisms of Intestinal Injury
- Effects of Environmental Toxins on the Small Intestine
- Role of Gut Microbiota in Toxicity
6. Toxicology of the Large Intestine and Colon
- Colonic Absorption and Excretion of Toxins
- Inflammatory Bowel Disease and Environmental Toxins
- Effects of Dietary Factors and Chemicals on the Colon
- Colorectal Cancer and Toxic Exposures
7. Hepatotoxicity and Its Impact on the Gastrointestinal System
- Mechanisms of Liver Injury from Toxicants
- Hepatic Metabolism of Toxic Compounds
- Drug-Induced Liver Injury (DILI)
- Liver Disease and Gastrointestinal Interactions
8. Toxicology of Gastrointestinal Enzymes and Proteins
- Role of Enzymes in the Toxicokinetics of Toxins
- Enzyme Inhibition and Toxicity
- Impact of Toxicants on Digestive Enzyme Systems
9. Chemical and Pharmaceutical Toxicology in the Gastrointestinal Tract
- Gastrointestinal Toxicity of Pharmaceuticals
- Drug-Induced GI Injury
- Gastrointestinal Effects of Over-the-Counter Medications
- Toxicological Assessment of Pharmaceutical Agents
10. Foodborne Toxins and Contaminants
- Naturally Occurring Toxins in Food
- Food Additives and Their Toxicological Impact
- Heavy Metals and Pesticides in the GI Tract
- Microbial Contaminants and Gastrointestinal Toxicity
11. Pathophysiology and Mechanisms of Gastrointestinal Toxicity
- Mechanisms of Toxicant-Induced Damage
- Role of Inflammation and Immune Responses
- Cellular Responses to Gastrointestinal Toxicants
12. Diagnosis and Management of Gastrointestinal Toxicity
- Clinical Diagnosis of GI Toxicity
- Diagnostic Tools and Techniques in Gastrointestinal Toxicology
- Therapeutic Approaches to Managing GI Toxicity
- Prevention and Risk Management of GI Toxicity
13. Regulatory and Safety Considerations in Gastrointestinal Toxicology
- Regulatory Guidelines for GI Toxicology Studies
- Risk Assessment in Gastrointestinal Toxicology
- Ethical and Legal Considerations in Toxicology Research
14. Future Directions in Gastrointestinal Toxicology Research
- Emerging Areas in GI Toxicology
- The Role of Genomics and Personalized Medicine
- Advances in Toxicology Testing and Modeling
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