Toxicogenomics and Proteomics 1st Edition by James Valdes, Jennifer Sekowski ISBN 1586034022 978-1586034023
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Product details:
ISBN 10: 1586034022
ISBN 13: 978-1586034023
Author: James J. Valdes, Jennifer W. Sekowski
Toxicology uses a variety of models to assess the behavioral and histopathological consequences of exposure to certain chemicals, primarily those described here as “environmental insults.” While useful to some degree, these assessments are not particularly helpful in determining the outcome of low-level exposure, or exposure to several chemicals, and they do not offer sufficient explanations of outcomes on the molecular level. In this collection of 15 papers, contributors describe research in new studies of gene activity which make it possible to develop a predictive toxicology based on analyses of the genome, proteome, and metabolome. The collection includes papers on classic toxicology as well as the new fields of research. Also, because developing nations tend to have the toxicological problems while developed nations tend to have the latest technological developments, the collection includes papers addressing toxicology in public health research. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)
Table of contents:
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Systems Biology
George Lake -
The Role of Bioinformatics in Toxicogenomics and Proteomics
Bruno Sobral, Dana Eckart, Reinhard Laubenbacher and Pedro Mendes -
Interpretation of Global Gene Expression Data through Gene Ontologies
Jacques Retief, Joe Morris, Jill Cheng, Tarif Awad, Rusty Thomas and John Hogenesch -
Expanding the Information Window to Increase Proteomic Sensitivity and Selectivity
Paul Skipp, Mateen Farooqui, Karen Pickard, Yan Li, Alan G.R. Evans and C. David O’Connor -
Understanding the Significance of Genetic Variability in the Human PON1 Gene
Clement E. Furlong, Wan-Fen Li, Toby B. Cole, Rachel Jampsa, Rebecca J. Richter, Gail P. Jarvik, Diana M. Shih, Aaron Tward, Aldon J. Lusis and Lucio G. Costa -
Functional Genomics Methods in Hepatotoxicity
Wilbert H.M. Heijne, Rob H. Stierum, Robert-Jan A.N. Lamers and Ben van Ommen -
The Toxicogenomics of Low-level Exposure to Organophosphate Nerve Agents
Jennifer Weeks Sekowski, Maryanne Vahey, Martin Nau, Mary Anne Orehek, Stephanie Mahmoudi, Jennifer Bucher, Jay Hanas, Kevin O’Connell, Akbar Khan, Mike Horsmon, Darrel Menking, Christopher Whalley, Bernard Benton, Robert Mioduszewski, Sandra Thomson and James J. Valdes -
Molecular Biomarkers of
Soheir Saad Korra -
Expression Profiling of Sulfur Mustard Exposure in Murine Skin: Chemokines, Cytokines and Growth Factors
Carol L.K. Sabourin, Young W. Choi, Mindy K. Stonerock, Jack D. Waugh, Robyn C. Kiser, Michele M. Danne, Kristi L. Buxton, Robert P. Casillas, Michael C. Babin and John J. Schlager -
Further Progress in DNA Repair Puzzle in the Postgenomics Era
Janusz Kocik - Non-Ribosomal Peptide Synthetases for the Production of Bioactive Peptides with Syringomycin Synthetase as an Example
N. Leyla Acan - Bacterial Genomics and Measures for Controlling the Threat from Biological Weapons
Jaroslav Spizek, Jiri Janata, Jan Kopecky and Lucie Najmanova - An Evaluation of Toxins and Bioregulators as Terrorism and Warfare Agents
Slavko Bokan - Prospects on Immunoassays for the Detection of Pesticides in the Environment
Nabil A. Mansour and Ahmed S. Alassuity - Prospects for Holographic Optical Tweezers
Joseph S. Plewa, Timothy Del Sol, Robert W. Lancelot, Ward A. Lopes, Daniel M. Mueth, Kenneth F. Bradley and Lewis S. Gruber
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Tags: James Valdes, Jennifer Sekowski, Toxicogenomics and Proteomics