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Thrombocytopenia 1st Edition by Mccrae Keith ISBN 978-0824725853 184569418X

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Author(s): R. McCrae Keith
ISBN(s): 9780824725853, 0824725859
Edition: 1
File Details: PDF, 2.29 MB
Year: 2006
Language: english
SKU: EB-1230464 Category: Tag:

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Product details: 

ISBN 10:   184569418X

ISBN 13: 978-0824725853

Author:  R. Mccrae Keith

The first and only source to offer an all-encompassing approach to the pathogenesis and treatment of thrombocytopenic disorders, this book reviews current information concerning thrombocytopenia due to diminished platelet production and accelerated immunologic and nonimmunologic platelet clearance, as well as a detailed review of medications that cause this disorder.

Table of contents: 

PART I: THROMBOCYTOPENIA DUE TO DISORDERED PLATELET PRODUCTION

  1. Megakaryopoiesis and Platelet Formation
    Liyan Pang and Mortimer Poncz

    • Introduction

    • Formation of Megakaryocytes from Hematopoietic Stem Cells

    • Transcription Factor Involved in Gene Regulation During Megakaryopoiesis

    • Morphologically Recognizable Megakaryocytes

    • Platelet Formation and Release

    • References

  2. Thrombopoietin: Biology and Potential Clinical Applications
    David J. Kuter

    • Introduction

    • Thrombopoietic Growth Factors

    • Biology of Thrombopoietin

    • Recombinant Thrombopoietins and Thrombopoietin Mimetics

    • Clinical Studies of the Thrombopoietins

    • Safety of Thrombopoietin

    • Summary

    • References

  3. Congenital (Inherited, Familial) Thrombocytopenias (CTPs)
    James B. Bussel

    • Diagnosing Congenital Thrombocytopenia

    • Clinical Findings That Suggest Congenital Thrombocytopenic Disorders

    • Synthesizing the Findings to Reach a Diagnosis

    • Specific Inherited Thrombocytopenias

    • Management of Patients with Congenital Thrombocytopenias

    • Conclusions

    • References

  4. Thrombocytopenia Due to Deficient Platelet Production
    Marc J. Kahn and Cindy Leissinger

    • Introduction

    • Low TPO States and Conditions of TPO Hyporesponsiveness

    • Normal and Elevated TPO States

    • References

PART II: THROMBOCYTOPENIA DUE TO EXCESSIVE PLATELET DESTRUCTION

  1. Platelet Clearance
    Steven E. McKenzie and Michael P. Reilly

    • Normal Physiology

    • Pathophysiology-Immune Thrombocytopenia Syndromes

    • Pathophysiology-Thrombocytopenia and Thrombosis Syndromes

  2. Idiopathic Thrombocytopenic Purpura
    Douglas B. Cines and Victor Blanchette

    • Introduction

    • Pathogenesis

    • ITP in Adults

    • ITP in Children

    • References

  3. Drug-Induced Thrombocytopenia
    Richard H. Aster and James N. George

    • Introduction

    • Pathophysiology of Drug-Induced Thrombocytopenia

    • Laboratory Diagnosis of Drug-Induced Thrombocytopenia

    • Clinical Diagnosis of Drug-Induced Thrombocytopenia

    • Drugs That Cause Thrombocytopenia

    • Clinical Course of Drug-Induced Thrombocytopenia

    • References

  4. Heparin-Induced Thrombocytopenia
    Theodore E. Warkentin

    • Overview

    • Pathogenesis

    • Laboratory Testing for HIT Antibodies

    • Frequency

    • Clinical Picture

    • Treatment

    • References

  5. Neonatal Alloimmune Thrombocytopenia
    Cecile Kaplan

    • Pathophysiology

    • Clinical Data

    • Laboratory Diagnosis

    • Neonatal Therapy

    • Antenatal Management of High-Risk Pregnancies

    • Routine Antenatal Screening

    • Conclusions

    • References

  6. Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
    Keith R. McCrae, Douglas B. Cines, and J. Evan Sadler

  • Introduction

  • Thrombotic Thrombocytopenic Purpura (TTP)

  • Hemolytic Uremic Syndrome

  • Miscellaneous Causes of Thrombotic Microangiopathy

  • References

  1. Thrombocytopenia in Pregnancy
    Keith R. McCrae

  • Introduction

  • Causes of Thrombocytopenia in Pregnancy

  • References

  1. Platelet Transfusion: Indications and Adverse Effects
    Janice McFarland

  • Introduction

  • Platelet Products

  • Indications for Platelet Transfusions

  • Diseases in which Platelet Transfusions are Indicated

  • Contraindications to Platelet Transfusions

  • Transfusion Practice

  • Adverse Events with Platelet Transfusion

  • References

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