Therapeutic Peptides and Proteins Formulation Processing and Delivery Systems Third Edition by Ajay Banga ISBN 146656606X 978-1466566064

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Product details: 

ISBN 10: 146656606X

ISBN 13:  978-1466566064

Author: Ajay K. Banga 

There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis.

The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature.

Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book:

• Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form
• Discusses the physical and chemical pathways of peptide and protein degradation
• Includes a detailed discussion of protein formulation and lyophilization
• Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations
• Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery

Table of contents: 

FORMULATION AND PROCESSING
Pharmaceutical Biotechnology: The Arrival of Recombinant Proteins
What Is Biotechnology?
Biotechnology Industry
Regulatory Aspects of Biotechnology-Derived Drugs
Immunogenicity of Proteins
Structure-Based Drug Design
Conclusions
References
Structure and Analysis of Therapeutic Peptides and Proteins
Amino Acids: Building Blocks of Proteins
Structure of Peptides and Proteins
Protein Conformation and Other Structural Features
Analytical Methods
Conclusions
References
Stability of Therapeutic Peptides and Proteins
Introduction

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Tags: Ajay Banga, Therapeutic Peptides, Proteins Formulation, Processing and Delivery