The Somatotrophic Axis in Brain Function 1st Edition by Fred Nyberg ISBN 978-0120884841 0120884844

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Product details: 

ISBN 10: 0120884844

ISBN 13: 978-0120884841

Author:  Fred Nyberg

The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.

Contents are well balanced and cover a variety of relevant topics from basic to clinical researchInternational selection of authors, with a good representation of the research on growth hormonesA timely publication which will be useful to scientists in both basic and clinical research

Table of contents: 

I. Biosynthesis of GH and IGF-I and Regulation of Their Secretion
1 Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion
C. B. Chan, Margaret C. L. Tse, and Christopher H.K. Cheng

2 Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor
Masayasu Kojima and Kenji Kangawa

II. GH and IGF-I and Their Function at Receptor Level
3 Mechanisms of Signal Transduction Utilized by Growth Hormone
Farhad Shafiei, Adrian C. Herington, and Peter E. Lobie

4 Insulin-like Growth Factor-I and its Binding Proteins: Regulation of Secretion and Mechanism of Action at Receptor Level
Mark G. Slomiany and Steven A. Rosenzweig

III. GH/IGF-I and Their Receptors in the CNS
5 Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid
Fred Nyberg

6 Growth Hormone, Insulin, and IGF-I: Do They Interact at the Blood-Brain Barrier?
Weihong Pan, Yongmei Yu, Fred Nyberg, and Abba J. Kastin

7 Growth Hormone and Insulin-like Growth Factors in the CNS: Localisation in Mammalian Species
Vincenzo C. Russo and George A. Werther

8 Purification of Growth Hormone Receptors from Human Brain Tissues
Zhennan Lai and Fred Nyberg

9 Growth Hormone Receptor Message in the Rat and Human CNS: Structure and Function
Madeleine Le Greves

IV. CNS Action of Growth Hormone: Animal Models
10 Interaction of Growth Hormone and Prolactin in Brain Circuits
David R. Grattan and Tanja A. E. Möderscheim

11 Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain
N. David Åberg, Maria A. I. Åberg, and Peter S. Eriksson

12 Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions
N. David Åberg

13 Rodent Models for the Study of the Role of GH-IGF-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction
Isao Shimokawa

14 Growth Hormone and Insulin-like Growth Factor-I (IGF-I) and Their Interactions with Brain Circuits Involved in Cognitive Function
Melinda Ramsey and William E. Sonntag

15 IGF-I and Neuroprotection
E. Carro, J. L. Trejo, S. Fernandez, A. M. Femandez, and I. Torres-Aleman

V. GH Replacement Therapy: CNS Benefits
16 Quality of Life in Adult GH Deficiency
Robert D. Murray and Stephen M. Shalet

17 The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology
Harald Jörn Schneider and Günter Karl Stalla

18 Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality
Åse Krogh Rasmussen and Ulla Feldt-Rasmussen

19 Psychological Importance to the Child of Growth Hormone Replacement
John Eric Chaplin, Jovanna Dahlgren, Berit Kriström, and Kerstin Albertsson Wikland

20 Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations
Sigbritt Werner

21 Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia
E. Arvat, R. Giordano, Micaela Pellegrino, Fabio Lanfranco, Matteo Baldi, Andreea Picu, Lorenza Bonelli, and E. Ghigo

22 Cognitive Status of Adult GHD Patients and GH-Induced Neuropsychological Changes
Jan Berend Deijen and Lucia. I. Arwert

23 Growth Hormone and Insulin-like Growth Factor-I in Alzheimer’s Disease
José Manuel Gómez

VI. GH Replacement and Related Therapies: Future Perspectives
24 Growth Hormone Antagonists – A Pharmacological Tool in Present and Future Therapies
John J. Kopchick, Lingua Qiu, Elahu Gosney, Chad Keller, Amanda Palmer, and Sudha Sankaran

25 Growth Hormone Replacement Therapy and Life Quality: Future Perspectives
Peter Sonksen

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