The Ischemic Penumbra Neurological Disease and Therapy 1st Edition by Geoffrey Donnan, Jean-Claude Baron, Stephen Davis, Frank Sharp ISBN 0849339901 978-0849339905
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The Ischemic Penumbra Neurological Disease and Therapy 1st Edition by Geoffrey A. Donnan, Jean-Claude Baron, Stephen M. Davis, Frank R. Sharp – Ebook PDF Instant Download/Delivery: 0849339901, 978-0849339905
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Product details:
ISBN 10: 0849339901
ISBN 13: 978-0849339905
Author: Geoffrey A. Donnan, Jean-Claude Baron, Stephen M. Davis, Frank R. Sharp
The Ischemic Penumbra presents the current status of concepts and research on this topic and identifies the latest methods for clinicians to quickly and efficiently recognize viable cerebral tissue for enhanced stroke management. Focusing on state-of-the-science technologies and current trends, the book examines imaging strategies utilizing PET, SPECT, MR, and CT for improved identification of key areas for intervention and therapy in the management of stroke patients.
With chapters by international authorities on the topic―including the originator of the ischemic penumbra concept, Professor Lindsay Symon―this volume provides a comprehensive view of the ischemic penumbra ranging from neurochemical processes to clinical implications, imaging, and therapy. It contains the first authoritative discussion of the thresholds and duration of the ischemic penumbra documented in various species, with sections that outline cerebral blood flow levels and their effects on important biochemical parameters. The book also supplies an authoritative series of chapters individually focused on current imaging techniques to target the location and extent of the penumbra. It outlines the relevance of the ischemic penumbra to specific therapies, such as extending time windows for therapy, and studies the determination of the presence of penumbra using a novel imaging/clinical mismatch concept, with clinical evidence and validation to date.
Table of contents:
1 The Ischaemic Penumbra An Overview
2 The Ischaemic Penumbra The Beginning
3 The Ischaemic Penumbra Overview Definition and Criteria
4 Perfusion Thresholds in Cerebral Ischaemia
5 Duration and Thresholds of the Ischemic Penumbra in Different Species
6 The Ischaemic Cascade Events Within the Penumbra
7 Multimodal Mapping of the Ischaemic Penumbra in Animal Models
8 Molecular Biology of the Penumbra
9 Selective Neuronal Loss
10 Inflammation and Reperfusion Injury Within the Penumbra
11 Imaging the Penumbra with PET Flumazenil
12 Imaging the Penumbra PET FMISO
13 Can the Penumbra be Imaged Using SPECT
14 Imaging the Penumbra with MR in Animals
15 Penumbra Imaged with MRI in Humans
16 Imaging the Penumbra with CT
17 MR Imaging the Ischemic Penumbra New Techniques
18 Clinical Imaging Mismatch
19 The Topography of the Ischaemic Penumbra
20 The Penumbra and Intracerebral Hemorrhage
21 Extending the Time Window for Therapy
22 MR in the Selection for Stroke Therapies
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Geoffrey Donnan,Jean-Claude Baron,Stephen Davis,Frank Sharp,The Ischemic Penumbra,Neurological Disease