T Cell Regulation in Allergy Asthma and Atopic Skin Diseases Chemical Immunology 1st Edition by Kurt Blaser, Johannes Ring, Monique Capron, Judah Denburg, Stephen Holgate ISBN 3805586280 978-3805586283

T Cell Regulation in Allergy Asthma and Atopic Skin Diseases Chemical Immunology 1st Edition by Kurt Blaser, Johannes Ring, Monique Capron, Judah A. Denburg, Stephen T. Holgate  – Ebook PDF Instant Download/Delivery: 3805586280, 978-3805586283
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Product details: 

ISBN 10: 3805586280 

ISBN 13: 978-3805586283

Author: Kurt Blaser, Johannes Ring, Monique Capron, Judah A. Denburg, Stephen T. Holgate

This book presents the state of the art in cellular and molecular mechanisms regulating the immune response in allergic inflammation. Special attention is given to the central role of regulatory T cells (Treg) in immune regulation and induction of peripheral tolerance, as well as to the relevance of Th17 cells in chronic inflammation. The importance of Treg and Th17 cells is demonstrated in bronchial asthma, atopic eczema, contact dermatitis and delayed-type hypersensitivity. Furthermore, T-cell-mediated regulatory mechanisms in helminthic infections and fungal allergy are discussed. Several chapters are devoted to the therapeutic consequences that these recently discovered T-cell functions may have. Their role as a potential target for specific immunotherapy is evaluated and novel approaches for peripheral tolerance induction and treatment of allergic and asthmatic diseases and inflammation are suggested. Stem cell transplantation as a future therapeutic intervention in regulatory T-cell disorders is also considered.
Well edited and up to date, this volume is recommended reading for allergologists, immunologists, dermatologists and any scientist interested in the immunological events regulating allergic inflammation in general and allergic manifestations in different organs.

Table of contents: 

1 Th17 and Treg Cells Innovate the Th1/Th2 Concept and Allergy Research
2 Regulatory T Cells and Antigen-Specific Tolerance
3 Molecular Mechanisms of Regulatory T-Cell Development
4 Interaction of Regulatory T Cells with Antigen-Presenting Cells in Health and Disease
5 Mucosal Regulatory T Cells in Airway Hyperresponsiveness
6 Natural Killer Cells in Allergic Inflammation
7 Mast Cells and Mast Cell-Derived Factors in the Regulation of Allergic Sensitization
8 Regulatory Effects of Histamine and Histamine Receptor Expression in Human Allergic Immune Responses
9 T-Cell Regulation in Asthmatic Diseases
10 Immune Regulatory Mechanisms in Allergic Contact Dermatitis and Contact Sensitization
11 Regulatory Role of T Lymphocytes in Atopic Dermatitis
12 T-Cell Regulation in Helminth Parasite Infections: Implications for Inflammatory Diseases
13 Immune Regulation and Tolerance to Fungi in the Lungs and Skin
14 Control of Delayed-Type Hypersensitivity by Ocular-Induced CD8+ Regulatory T Cells
15 Novel Therapeutic Strategies by Regulatory T Cells in Allergy
16 T-Cell Regulatory Mechanisms in Specific Immunotherapy
17 Control and Regulation of Peripheral Tolerance in Allergic Inflammatory Disease: Therapeutic Consequences
18 Lung Dendritic Cells: Targets for Therapy in Allergic Disease
19 Antigen-Based Therapies Targeting the Expansion of Regulatory T Cells in Autoimmune and Allergic Disease
20 Stem Cell Transplantation in Genetically Linked Regulatory T-Cell Disorders
21 Author Index
22 Subject Index

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Kurt Blaser, Johannes Ring, Monique Capron, Judah A. Denburg, Stephen T. Holgate