(Ebook PDF) Suppressing the Mind Anesthetic Modulation of Memory and Consciousness 1st Edition by Anthony Hudetz, Robert Pearce ISBN 1607614634 9781607614630 Full chapter

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ISBN 10:         1607614634
ISBN 13: 978-1607614630
Author:          Anthony Hudetz, Robert Pearce

Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the field well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation of memory. Seven of the chapters are based on material presented at these symposia – appropriately updated with new relevant findings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of “anesthesia awareness,” a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.

Suppressing the Mind Anesthetic Modulation of Memory and Consciousness 1st Table of contents:

1. Molecular Targets of General Anesthetics in the Nervous System

• Overview of how anesthetics interact with molecular targets in the brain.

2. A Neurochemical Perspective on States of Consciousness

• Examining the chemical pathways that define consciousness and unconsciousness under anesthesia.

3. Anesthetic Modulation of Auditory Perception: Linking Cellular, Circuit, and Behavioral Effects

• How anesthesia influences auditory processing at various levels of the nervous system.

4. Cortical Disintegration: Mechanism of Anesthetic-Induced Unconsciousness

• Understanding the breakdown of cortical activity leading to loss of consciousness during anesthesia.

5. Anesthesia and the Thalamocortical System

• Role of the thalamocortical system in mediating anesthetic effects and consciousness states.

6. Anesthesia-Induced State Transitions in Neuronal Populations

• Investigating how anesthetics trigger transitions in neuronal activity and population dynamics.

7. Anesthesia Awareness: When the Mind is Not Suppressed

• Examining the phenomenon of anesthesia awareness, when the brain remains conscious despite physical anesthesia.

8. Loss of Recall and the Hippocampal Circuit Effects Produced by Anesthetics

• Exploring how anesthetics affect the hippocampus and lead to memory loss.

9. Modulation of the Hippocampal Rhythm as a Mechanism for Anesthetic-Induced Amnesia

• Studying how changes in hippocampal rhythms contribute to amnesia during anesthesia.

10. Propofol Amnesia – What is Going on in the Brain?

• Understanding the brain mechanisms behind propofol-induced memory loss.

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