Skeletal Muscle As a Response Target The Link Between Growth and Metabolism 1st Edition by M B Ranke, V Popovic brkic ISBN 3805582447 9783805582445

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ISBN 10: 3805582447 
ISBN 13: 9783805582445
Author: M B Ranke, V Popovic brkic

• Skeletal Muscle: More Than Just Movement

• The Dynamic Interplay of Growth, Metabolism, and Health

• Skeletal Muscle as an Endocrine Organ and Target Tissue

• Scope and Objectives of the Book

• Overview of Key Concepts and Chapter Organization

Skeletal Muscle As a Response Target The Link Between Growth and Metabolism 1st Table of contents:

Part I: Fundamental Biology of Skeletal Muscle

• Chapter 1: Skeletal Muscle Development and Regeneration

  • Myogenesis: From Satellite Cells to Mature Muscle Fibers

  • Muscle Fiber Types (Slow-twitch, Fast-twitch) and Their Characteristics

  • Muscle Regeneration and Repair Mechanisms

  • Impact of Development on Metabolic Capacity

• Chapter 2: Structure and Function of Muscle Fibers

  • Sarcomere Ultrastructure and Contraction Mechanisms

  • Excitation-Contraction Coupling

  • Mitochondrial Structure and Function in Muscle

  • Key Proteins Involved in Muscle Contraction and Energy Production

Part II: Hormonal Regulation of Muscle Growth and Metabolism

• Chapter 3: Growth Hormone and IGF-1 Axis

  • Synthesis, Secretion, and Regulation of Growth Hormone (GH)

  • Insulin-like Growth Factor 1 (IGF-1): Production and Receptor Signaling

  • Role of GH/IGF-1 in Muscle Hypertrophy and Anabolism

  • Impact on Glucose and Lipid Metabolism in Muscle

• Chapter 4: Insulin and Glucose Homeostasis in Muscle

  • Insulin Signaling Pathways in Skeletal Muscle

  • Glucose Uptake and Glycogen Synthesis

  • Insulin Sensitivity vs. Insulin Resistance in Muscle

  • Adipokines and Myokines: Cross-Talk with Adipose Tissue

• Chapter 5: Thyroid Hormones and Adrenal Hormones

  • Impact of Thyroid Hormones (T3, T4) on Muscle Metabolism and Fiber Type

  • Glucocorticoids (Cortisol) and Muscle Catabolism

  • Catecholamines and Muscle Energy Mobilization

• Chapter 6: Sex Steroids and Other Anabolic Hormones

  • Androgens (Testosterone) and Muscle Anabolism

  • Estrogens and Muscle Health

  • Myostatin: A Negative Regulator of Muscle Growth

  • Other Peptides and Factors Affecting Muscle Mass

Part III: Metabolic Pathways and Their Regulation in Muscle

• Chapter 7: Glucose and Glycogen Metabolism in Muscle

  • Glucose Transport (GLUT4)

  • Glycolysis and Lactate Production

  • Glycogenolysis and Glycogenesis in Resting and Exercising Muscle

  • Regulation of Glucose Flux

• Chapter 8: Lipid Metabolism in Skeletal Muscle

  • Fatty Acid Uptake and Oxidation

  • Intramyocellular Lipids (IMCLs)

  • Role of Mitochondria in Lipid Metabolism

  • Lipid Droplet Dynamics

• Chapter 9: Amino Acid and Protein Metabolism in Muscle

  • Protein Synthesis Pathways (mTOR pathway, etc.)

  • Protein Degradation Pathways (Ubiquitin-Proteasome System, Autophagy)

  • Amino Acid Transporters and Pool

  • Muscle Protein Turnover Balance

Part IV: Nutrition, Exercise, and Environmental Influences

• Chapter 10: Nutritional Impact on Muscle Growth and Metabolism

  • Protein Intake and Muscle Protein Synthesis

  • Carbohydrates and Glycogen Replenishment

  • Fats and Essential Fatty Acids

  • Micronutrients and Their Role in Muscle Function

• Chapter 11: Exercise as a Modulator of Muscle Growth and Metabolism

  • Resistance Training and Hypertrophy Signaling

  • Endurance Training and Metabolic Adaptations

  • Acute vs. Chronic Exercise Responses

  • Exercise-Induced Myokines

• Chapter 12: Environmental and Lifestyle Factors

  • Aging (Sarcopenia): Mechanisms and Interventions

  • Sedentary Lifestyle and Muscle Health

  • Impact of Chronic Disease (e.g., Cancer Cachexia, Diabetes)

  • Environmental Stressors

Part V: Clinical Implications and Therapeutic Strategies

• Chapter 13: Muscle Atrophy and Wasting Syndromes

  • Causes and Mechanisms of Muscle Wasting (Disuse, Disease, Malnutrition)

  • Molecular Targets for Preventing Muscle Loss

  • Pharmacological Interventions

• Chapter 14: Metabolic Disorders and Skeletal Muscle

  • Skeletal Muscle Insulin Resistance in Type 2 Diabetes

  • Mitochondrial Dysfunction in Metabolic Disease

  • Dyslipidemia and Muscle

• Chapter 15: Therapeutic Strategies and Future Directions

  • Nutritional and Exercise Interventions

  • Emerging Pharmacological Targets

  • Gene Therapy and Cell-Based Approaches

  • Precision Medicine in Muscle Health

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