(Ebook PDF) Scientific background to medicine 2 2nd Edition by John Firth, Emma Baker isbn 9781860162657 1860162657 full chapters

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ISBN 10:1860162657

ISBN 13:9781860162657

Author: John D Firth; Emma H Baker

Although every effort has been made to ensure that drug dosesand other information are presented accurately in this publication, theultimate responsibility rests with the prescribing physician. Neither thepublishers nor the authors can be held responsible for any consequencesarising from the use of information contained herein. Any productmentioned in this publication should be used in accordance with theprescribing information prepared by the manufacturers.The information presented in this publication reflects the opinions of itscontributors and should not be taken to represent the policy and views of theRoyal College of Physicians of London, unless this is specifically stated.Every effort has been made by the contributors to contact holders of copyright to obtain permission to reproduce copyrighted material. However,if any have been inadvertently overlooked, the publisher will be pleased tomake the necessary arrangements at the first opportunity

Table of Contents:

CLINICAL PHARMACOLOGY

Introducing Clinical Pharmacology
1.1 Risks versus benefits
1.2 Safe prescribing
1.3 Rational prescribing
1.4 The role of clinical pharmacology

Pharmacokinetics
2.1 Introduction
2.2 Drug absorption
2.3 Drug distribution
2.4 Drug metabolism
2.5 Drug elimination
2.6 Plasma half-life and steady-state plasma concentrations
2.7 Drug monitoring

Pharmacodynamics
3.1 How drugs exert their effects
3.2 Selectivity is the key to the therapeutic utility of an agent
3.3 Basic aspects of the interaction of a drug with its target
3.4 Heterogeneity of drug responses, pharmacogenetics, and pharmacogenomics

Prescribing in Special Circumstances
4.1 Introduction
4.2 Prescribing and liver disease
4.3 Prescribing in pregnancy
4.4 Prescribing for women of childbearing potential
4.5 Prescribing to lactating mothers
4.6 Prescribing in renal disease
4.7 Prescribing in the elderly

Adverse Drug Reactions
5.1 Introduction and definition
5.2 Classification of adverse drug reactions
5.3 Clinical approach to adverse drug reactions
5.4 Dose-related adverse drug reactions (type A)
5.5 Non-dose-related adverse drug reactions (type B)
5.6 Adverse reactions caused by long-term effects of drugs (type C)
5.7 Adverse reactions caused by delayed effects of drugs (type D)
5.8 Withdrawal reactions (type E)
5.9 Drugs in overdose and use of illicit drugs

Drug Development and Rational Prescribing
6.1 Drug development
6.2 Rational prescribing
6.3 Clinical governance and rational prescribing

STATISTICS, EPIDEMIOLOGY, CLINICAL TRIALS AND META-ANALYSES
Statistics
Epidemiology
2.1 Observational studies
Clinical Trials and Meta-Analyses

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