RNA Interference Challenges and Therapeutic Opportunities 1st Edition by Mouldy Sioud ISBN 978-1493915378 1493915371

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Product details: 

ISBN 10:  1493915371

ISBN 13: 978-1493915378

Author: Mouldy Sioud

RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA’s unwanted effects. Preclinical and clinical use of synthetic siRNAs, the roles of miRNAs in cancer and the promise of extracellular miRNAs for diagnosis are also covered in this meticulous collection, along with novel methods for identifying endogenous siRNAs and the annotation of small RNA transcriptomes. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and key implementation advice that ensures successful results in the laboratory.

Comprehensive and cutting-edge, RNA Interference: Challenges and Therapeutic Opportunities will aid researchers, clinicians, teachers and biotechnologists interested in the power of RNA-based therapies.

Table of contents: 

1 RNA Interference: Mechanisms, Technical Challenges, and Therapeutic Opportunities. Mouldy Sioud

2 Nanostructured RNAs for RNA Interference. Yuko Nakashima, Naoko Abe, Yoshihiro Ito, and Hiroshi Abe

3 One Long Oligonucleotide or Two Short Oligonucleotides Based shRNA Construction and Expression Xue-jun Wang and Sheng-qi Wang

4 PLGA Microspheres Encapsulating siRNA Giuseppe De Rosa and Giuseppina Salzano

5 Magnetic Nanoparticle and Magnetic Field Assisted siRNA Delivery In Vitro

Olga Mykhaylyk, Yolanda Sanchez-Antequera, Dialechti Vlaskou, Maria Belen Cerda, Mehrdad Bokharaei, Edelburga Hammerschmid, Martina Anton, and Christian Plank

6 Cytoplasmic Delivery of siRNAs to Monocytes and Dendritic Cells via Electroporation Mouldy Sioud

7 Delivery of siRNAs to Cancer Cells via Bacteria. Omar Ahmed, Andrea Krühn, and Hermann Lage

8 Microwell Array-Mediated Delivery of Lipoplexes Containing Nucleic Acids for Enhanced Therapeutic Efficacy Yun Wu, Daniel Gallego-Perez, and L. James Lee

9 Modulating the Tumor Microenvironment with RNA Interference as a Cancer Treatment Strategy Karin Zins, Mouldy Sioud, Seyedhossein Aharinejad, Trevor Lucas, and Dietmar Abraham

10 Targeted In Vivo Delivery of siRNA and an Endosome-Releasing Agent to Hepatocytes. Magdolna G. Sebestyén, So C. Wong, Vladimir Trubetskoy, David L. Lewis, and Christine I. Wooddell

11 Cell-Internalization SELEX: Method for Identifying Cell-Internalizing RNA Aptamers for Delivering siRNAs to Target Cells. William H. Thiel, Kristina W. Thiel, Katie S. Flenker, Tom Bair, Adam J. Dupuy, James O. McNamara II, Francis J. Miller, and Paloma H. Giangrande

12 Strategies for siRNA Navigation to Desired Cells. Mouldy Sioud

13 Use of Guanidinopropyl-Modified siRNAs to Silence Gene Expression Maximilian C.R. Buff, Stefan Bernhardt, Musa D. Marimani, Abdullah Ely, Joachim W. Engels, and Patrick Arbuthnot

14 Therapy of Respiratory Viral Infections with Intranasal siRNAs. Sailen Barik and Patrick Lu

15 Engineering Therapeutic Cancer Vaccines That Activate Antitumor Immunity Per Ole Iversen and Mouldy Sioud

16 Immunosuppressive Factor Blockade in Dendritic Cells via siRNAs Results in Objective Clinical Responses. Mouldy Sioud, Anne Mobergslien, and Stein Sabge-Larssen

17 Targeting ber-abl Transcripts with siRNAs in an Imatinib-Resistant Chronic Myeloid Leukemia Patient: Challenges and Future Directions Michael Koldehoff

18 A Facile Method for Interfering with Off-Target Silencing Mediated by the Sense Strand. Anne Mobergslien and Mouldy Sioud

19 Overcoming the Challenges of siRNA Activation of Innate Immunity: Design Better Therapeutic siRNAs Mouldy Sioud

20 Gene Silencing In Vitro and In Vivo Using Intronic MicroRNAs Jia Han Deng, Peter Deng, Shi-Lung Lin, and Shao-Yao Ying

21 In Silico Identification of Novel Endo-siRNAs Andrew Schuster, Grant W. Hennig, Nicole Ortogero, Dickson Luong, and Wei Yan

22 Computer-Assisted Annotation of Small RNA Transcriptomes. Nicole Ortogero, Grant W. Hennig, Dickson Luong, and Wei Yan

23 miR-CATCH: MicroRNA Capture Affinity Technology Sebastian Vencken, Tidi Hassan, Noel G. McElvaney, Stephen G.J. Smith, and Catherine M. Greene

24 Roles of MicroRNAs in Cancers and Development Shigeru Takasaki

25 Targeting MicroRNAs to Prevent Cancer Metastasis. Valentina Profumo, Valentina Doldi, Paolo Gandellini, and Nadia Zaffaroni

26 Urinary MicroRNAs as a New Class of Noninvasive Biomarkers in Oncology, Nephrology, and Cardiology Hana Mlcochova, Renata Hezova, Albano C. Meli, and Ondrej Slaby

27 Magnetic Bead-Based Isolation of Exosomes.

Morten P. Oksvold, Axl Neurauter, and Ketil W. Pedersen

28 Modified 2′-Ribose Small RNAs Function as Toll-Like

Receptor-7/8 Antagonists.

Mouldy Sioud

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Tags: Mouldy Sioud, RNA Interference, Challenges and Therapeutic