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Protein ligand Interactions Methods and Applications 1st Edition. Edition G. Ulrich Nienhaus Digital Instant Download

Author(s): G. Ulrich Nienhaus
ISBN(s): 9781617375255, 161737525X
Edition: 1st Edition.
File Details: PDF, 5.66 MB
Year: 2010
Language: english
SKU: EB-1290924 Category: Tag:

Protein ligand Interactions Methods and Applications 1st Edition by G. Ulrich Nienhaus – Ebook PDF Instant Download/Delivery: 161737525X, 978-1617375255
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Product details:

ISBN 10:         161737525X
ISBN 13: 978-1617375255
Author:        G. Ulrich Nienhaus  

A readily reproducible collection of established and emerging techniques for studying the interaction between proteins and ligands, including biochemical/bulk techniques, structure analysis, spectroscopy, single-molecule studies, and theoretical/computational tools. Among the highlights are surface plasmon resonance (SPR) and reflectometric biosensor approaches, high-throughput screening with confocal optics microscopy, single molecule fluorescence and fluorescence correlation spectroscopy (FCS), atomic force microscopy (AFM), crystallography of reaction intermediates, and time-resolved x-ray crystallography. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
 

Protein ligand Interactions Methods and Applications 1st Table of contents:

 

Here is a speculative Table of Contents for Protein-Ligand Interactions: Methods and Applications (1st edition), based on typical content in books dealing with this subject:

Table of Contents

1. Introduction to Protein-Ligand Interactions

  • Basic Concepts and Terminology
  • The Importance of Protein-Ligand Interactions in Drug Design
  • Types of Ligands and Their Binding Modes

2. Thermodynamics of Protein-Ligand Binding

  • Binding Affinity and Thermodynamic Parameters
  • Enthalpy and Entropy in Binding Interactions
  • Measurement of Binding Thermodynamics

3. Structural Characterization of Protein-Ligand Complexes

  • X-ray Crystallography
  • Nuclear Magnetic Resonance (NMR) Spectroscopy
  • Cryo-Electron Microscopy (Cryo-EM)
  • Computational Modeling and Docking Studies

4. Methods for Measuring Protein-Ligand Binding

  • Surface Plasmon Resonance (SPR)
  • Isothermal Titration Calorimetry (ITC)
  • Fluorescence Spectroscopy
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Differential Scanning Fluorimetry (DSF)

5. Computational Approaches to Protein-Ligand Interactions

  • Molecular Docking and Scoring Functions
  • Molecular Dynamics Simulations
  • Ligand-Based Virtual Screening
  • Structure-Based Drug Design

6. High-Throughput Screening for Drug Discovery

  • Screening Techniques and Technologies
  • Assay Development and Optimization
  • Case Studies of Successful Drug Discovery Campaigns

7. Applications in Drug Design and Development

  • Target Identification and Validation
  • Lead Discovery and Optimization
  • ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) Considerations
  • Case Studies in Drug Discovery

8. Protein-Ligand Interaction Databases and Resources

  • PDB (Protein Data Bank)
  • PubChem and ChEMBL
  • BindingDB and other Ligand Databases

9. Challenges and Future Directions

  • Overcoming Drug Resistance
  • Allosteric Modulation and Beyond
  • The Role of Artificial Intelligence in Drug Discovery
  • Future Trends in Protein-Ligand Interaction Studies

10. Conclusion

  • Summary of Key Concepts
  • The Future of Protein-Ligand Interaction Research

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