Pharmacology of Purine and Pyrimidine Receptors 1st Edition by Kenneth Jacobson, Joel Linden 0123855268 9780123855268

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ISBN 10:         0123855268
ISBN 13: 978-0123855268
Author:          Kenneth A. Jacobson, Joel Linden

Pharmacology of Purine and Pyrimidine Receptors 1st Table of contents:

Chapter 1: The Structure of the Adenosine Receptors
I. Introduction
II. Primary Sequence and Covalent Modifications of the Adenosine A2A Receptors
III. The A2AAR Crystal Structure
IV. Binding Selectivity Across the ARs
V. Receptor Structure and Receptor Homology Modeling
VI. In Silico Screening
VII. Conclusion
References

Chapter 2: Adenosine Receptors in Health and Disease
I. Introduction
II. A1 Adenosine Receptors
III. A2A Adenosine Receptors
IV. A2B Adenosine Receptors
V. A3 Adenosine Receptors
VI. Conclusion
References

Chapter 3: Adenosine and the Regulation of Metabolism and Body Temperature
I. Introduction: The Concept of Adenosine as an Emergency Signal
II. Adenosine and the Regulation of Lipid Metabolism
III. Adenosine and Glucose Homeostasis
IV. Central Regulation of Metabolism, Sleep, and Wakefulness
V. Regulation of Temperature
VI. Conclusion
Acknowledgments
References

Chapter 4: Regulation of Leukocyte Function by Adenosine Receptors
I. Introduction
II. Immune Responses to Adenosine Receptor Signaling
III. Disease Relevance of Adenosine to Immune Signaling
IV. Conclusion
Disclosure Statement
References

Chapter 5: Receptors in Inflammation
I. Introduction
II. Tools to Study A2B Adenosine Receptor Function
III. A2B Receptors on Immune Cells
IV. A2B Receptors on Endothelial Cells
V. A2B Receptors on Epithelial Cells
VI. Role of A2B Receptors on Fibroblasts
VII. Role of A2B Receptors in Animal Models of Inflammation
VIII. Conclusions
Acknowledgments
References

Chapter 6: Adenosine Receptors in Tissue Protection
I. Introduction
II. Relationship Between Hypoxia and Inflammation
III. Effect of Hypoxia on the Extracellular Availability of Adenosine
IV. Alteration of ADORA2B Signaling by Hypoxia
V. Examples of ADORA2B Signaling in Tissue Protection from Hypoxia
VI. Other ARs than the ADORA2B During Hypoxia
VII. Conclusion
Acknowledgment
References

Chapter 7: Allosteric Modulation of Purine and Pyrimidine Receptors
I. Introduction
II. AR Modulators
III. “Translational” Assessment of a Prototypical PAM of A1 AR
IV. Allosteric Modulators of P2Y and P2X Receptors for Nucleotides
V. Conclusion
Acknowledgments
References

Chapter 8: Molecular Mechanisms of Purine and Pyrimidine Nucleotide Release
I. Introduction
II. Nucleotide Release Is a Feature of Living Cells
III. Mechanisms of Nucleotide Release
IV. Conclusion
Acknowledgments
References

Chapter 9: Impact of Ectoenzymes on P2 and P1 Receptor Signaling
I. Introduction
II. Enzymes Metabolizing Extracellular Nucleotides
III. Examples of Physiological Roles of Ectoenzymes in P2 and P1 Signaling
IV. Note on Ectonucleotidase Inhibitor Development
V. Conclusion
Acknowledgments
References

Chapter 10: Ectonucleotidases as Regulators of Purinergic Signaling in Thrombosis, Inflammation, and Immunity
I. Introduction
II. Purinergic Signaling: A Paradigm Linking Coagulation, Inflammation, and Immunity
III. Extracellular Nucleotides, Nucleosides, and Ectonucleotidases
IV. Purinergic Signaling Responses in the Vasculature and Immune Systems
V. Hemostasis and Thrombosis
VI. Inflammation
VII. Immunity
VIII. Disease Processes
IX. Conclusion
Acknowledgments
References

Chapter 11: P2X Receptors in Health and Disease
I. Introduction
II. Molecular Physiology of P2X Receptors
III. Distribution and Physiological Roles of P2X Receptors
IV. Pathophysiology of P2X Receptors
V. Conclusion
References

Chapter 12: Molecular Pharmacology, Physiology, and Structure of the P2Y Receptors
I. Introduction
II. Signaling Through Heterotrimeric G Proteins
III. The P2Y Receptors
IV. P2Y Receptor Structure
V. Selective P2Y Receptor Ligands as Pharmacological Tools
VI. Conclusions
Acknowledgments
References

Chapter 13: P2Y Receptors in Health and Disease
I. Introduction
II. P2Y Receptors in Platelet Activation
III. Clopidogrel for the Treatment of ACS and STEMI
IV. Aspirin and Clopidogrel Resistance
V. Novel ADP-Receptor Blockers for the Treatment of ACS
VI. Pulmonary Disease
VII. Dry Eye Disease
VIII. Hypertension
IX. Migraine and Vascular Pain
X. Atherosclerosis
XI. Osteoporosis
XII. Diabetes
XIII. Cardioprotection
XIV. Oncology
XV. Conclusion
References

Chapter 14: P2 Receptor Signaling in Neurons and Glial Cells of the Central Nervous System
I. Introduction
II. The Source and Fate of Extracellular ATP
III. Recombinant P2 Receptors
IV. Signaling via P2 Receptors
V. Pharmacology of the P2 Receptors
VI. Distribution of P2 Receptors in the CNS
VII. Role of P2 Receptors in Neuronal and Glial Functions in the CNS
VIII. Involvement of the P2 Receptors in Physiological and Pathophysiological CNS Functions
IX. Conclusion
Acknowledgments
References

Chapter 15: Role of Purinergic Receptors in CNS Function and Neuroprotection
I. Introduction
II. The Role of Purinergic Receptors in Neuronal Cell Function and Survival
III. The Role of Purinergic Receptors in Astrocyte Function and Survival
IV. The Role of Purinergic Receptors in Microglial Function
V. The Role of Purinergic Receptors in Oligodendrocyte Function and Survival
VI. Conclusion

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