Oxygen Nitrogen Radicals Lung Injury and Disease Lung Biology in Health and Disease 1st Edition by Val Vallyathan, Vincent Castranova, Xianglin Shi ISBN 0824748743 978-0824748746

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Product details: 

ISBN 10:  0824748743 

ISBN 13: 978-0824748746

Author:  Val Vallyathan, Vincent Castranova, Xianglin Shi

Table of contents: 

1. Reactive Oxygen/Nitrogen Species: Generation and Reactions in the Lung

Ann E. Aust

I. Introduction

II. Reactive Oxygen Species

III. Reactive Nitrogen Species

IV. Further Reactions of ROS and RNS with Biological Molecules

V. Conclusions References

2. Oxidative Stress/Antioxidant Status in Health and Disease Val Vallyathan

I. Introduction

II. Antioxidants in Normal Healthy Lung

III. Antioxidants in Lung Diseases

IV. Oxidative Stress and Antioxidant Genes

V. Pharmacological Modulation and Clinical Benefits

VI. Conclusions References

3. Reactive Oxygen Species in the Activation and Regulation of Intracellular Signaling Events

Fei Chen and Vincent Castranova

I. Introduction

IL Sources of ROS

III. ROS and Signal Transduction

IV. Is p53 Regulated by or a Regulator for ROS?

V. ROS Regulation of Nuclear Factor of Activated T Cells

VI. Summary

References

4. Mediators of Lung Inflammation: Role of Reactive Oxygen and Nitrogen Species

Jayne S. Reuben, Ren-Feng Guo, and Peter A. Ward

I. Introduction

II. Immune Complex-Induced Injury as a Model for Oxidant-Mediated Lung Inflammation

III. Superoxide and Oxygen Radicals

IV. Nitric Oxide

V. Proteases

VI. Endogenous Mediators: Cytokines, Transcription Factors, Chemokines, and Adhesion Molecules

VII. Role of CSa in Acute Lung Inflammation

VIII. Clinical Relevance

IX. Conclusions References

5. Pulmonary Complications of Chronic Granulomatous Disease

Bernard M. Babior

1. Introduction

11. Molecular Basis of CGD and Defects in Oxidative

Metabolism

References

6. Genotoxic and Carcinogenic Mechanisms of Mineral Fibers: Role of Reactive Oxygen Species

Tom K. Hei, Ann Xu, and Yongliang Zhao

I. Introduction

II. Asbestos as a Gene and Chromosomal Mutagen

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III. Fiber-Cell Interaction in Mediating Genotoxic Response

IV. Detection of Oxy Radicals Produced by Asbestos Fibers

V. Effect of Depleted Intracellular Glutathione Level on Fiber Mutagenesis

VI. Induction of Oxidative DNA Damage by Asbestos Fibers

VII. Types of Mutations Induced by Asbestos Are Similar to Those of Hydrogen Peroxide

VIII. Transformation Studies with Human Epithelial Cells

IX. Gene Expression Profile in Asbestos-Induced Tumor Cells

X. Ectopic Expression of the Big-h3 Gene Suppressive Tumorigenicity

XI. Conclusion References

7. Influence of Mineral Dust Surface Characteristics and Generation of Reactive Species

David W. Kamp and Val Vallyathan

I. Introduction

II. Asbestos

III. Phyllosilicates and Coal

IV. Conclusions References

8. Oxygen/Nitrogen Radicals and Silica-Induced Diseases

Vincent Castranova and Val Vallyathan

1. Introduction

II. Generation of Reactive Oxygen Species from Crystalline Silica

III. Generation of Reactive Oxygen Species from Lung Cells Exposed to Silica

IV. Nitric Oxide Production by Lung Cells

V. Summary References

9. Asbestosis and Asbestos-Related Cancers: Role of Reactive Oxygen and Nitrogen Species

Arti Shukla and Brooke T. Mossman

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I. Introduction

II.

Diseases Caused by Asbestos

III. Generation of ROS/RNS by Asbestos

IV. Role of ROS/RNS in Asbestos-Associated Cellular Effects

V. Asbestos-Induced RNS Generation and Pulmonary Toxicity

VI. Summary References

10. Interactions of Exogenous or Evoked Reactive Oxygen Species and Inhaled Particles in the Lung

Andrew Churg

I. Introduction

II. Adhesion of Particles to Epithelial Cells

III. Particle Uptake and Retention by Epithelial Cells

IV. Exogenous or Evoked ROS and Pathological Reactions to Particles

V. Conclusions References

11. Smoking-Induced Inflammation, Injury, and Disease: Molecular Mechanisms

Irfan Rahman

I. Introduction

II. Cigarette Smoke and Oxidative Stress

III. ROS-Mediated Lipid Peroxidation Products and Their Role in Biochemical Processes

IV. Involvement of Cigarette Smoke-Mediated Lipid Peroxidation Products in Cell Signaling and Gene Transcription

V. Role of ROS and Cigarette Smoke-Induced Oxidative Stress in Chromatin Modeling: Role for Histone Acetylation/Deacetylation and DNA Methylation

VI. Conclusions References

12. Respiratory Health Effects of Ambient Air Pollution Particles: Role of Reactive Species

Ken Donaldson, L. Albert Jiménez, Irfan Rahman, Stephen P. Faux, William MacNee, Peter S. Gilmour.

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Tags: Val Vallyathan, Vincent Castranova, Xianglin Shi, Oxygen Nitrogen, Radicals Lung, Disease Lung