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Novel Therapeutic Targets for Antiarrhythmic Drugs 1st Edition by George Edward Billman ISBN 978-0470261002 0470261005

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Novel Therapeutic Targets for Antiarrhythmic Drugs 1st Edition George Edward Billman Digital Instant Download

Author(s): George Edward Billman
ISBN(s): 9780470261002, 0470261005
Edition: 1
File Details: PDF, 6.13 MB
Year: 2010
Language: english
SKU: EB-1471856 Category: Tag:

Novel Therapeutic Targets for Antiarrhythmic Drugs 1st Edition by George Edward Billman  – Ebook PDF Instant Download/Delivery: 978-0470261002, 0470261005
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Product details: 

ISBN 10:  0470261005

ISBN 13: 978-0470261002

Author: George Edward Billman

PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS

Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology.

Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections:

  • Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs.
  • Section Two addresses safety pharmacology, including the concept of “repolarization reserve,” safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs.
  • Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets.
  • Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids).

Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.

Table of contents: 

1 Introduction
2 Fundamental Mechanisms of Cardiac Electrophysiology
3 Ion Channels in the Heart
4 Excitation-Contraction Coupling
5 The Cardiac Action Potential
6 Cardiac Conduction System
7 Electrophysiology of the Sinoatrial Node
8 Electrophysiology of the Atrioventricular Node
9 Electrophysiology of the His-Purkinje System
10 Ventricular Electrophysiology
11 Atrial Electrophysiology
12 Autonomic Regulation of Cardiac Electrophysiology
13 Cellular Mechanisms of Arrhythmias
14 Reentrant Arrhythmias
15 Triggered Activity and Afterdepolarizations
16 Genetic Basis of Cardiac Arrhythmias
17 Long QT Syndrome
18 Brugada Syndrome
19 Catecholaminergic Polymorphic Ventricular Tachycardia
20 Short QT Syndrome
21 Early Repolarization Syndrome
22 Arrhythmogenic Right Ventricular Cardiomyopathy
23 Ion Channel Trafficking and Arrhythmias
24 Cardiac Memory
25 Electrophysiologic Effects of Ischemia and Infarction
26 Heart Failure and Electrophysiology
27 Remodeling of Ion Channels in Cardiac Disease
28 Atrial Fibrillation: Mechanisms and Substrates
29 Ventricular Tachycardia: Mechanisms and Substrates
30 Sudden Cardiac Death: Mechanisms and Risk Stratification
31 Role of Fibrosis in Arrhythmogenesis
32 Animal Models of Cardiac Electrophysiology
33 Computational Models of Cardiac Electrophysiology
34 Optical Mapping of Cardiac Electrophysiology
35 Patch-Clamp Techniques in Cardiac Research
36 ECG Interpretation and Electrophysiology
37 Signal Processing in Cardiac Electrophysiology
38 Noninvasive Mapping of Cardiac Electrical Activity
39 Ablation Techniques for Cardiac Arrhythmias
40 Implantable Devices in Electrophysiology
41 Antiarrhythmic Drug Therapy
42 Gene and Cell Therapy for Arrhythmias
43 Future Directions in Cardiac Electrophysiology

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Tags: George Edward Billman, Novel Therapeutic, Targets for Antiarrhythmic