Mouse Models for Drug Discovery Methods and Protocols 1st Edition by Michael Festing, Gabriele Proetzel, Michael Wiles ISBN 9781607610571 1607610574

Mouse Models for Drug Discovery Methods and Protocols 1st Edition by Michael F.W. Festing, Gabriele Proetzel, Michael V. Wiles- Ebook PDF Instant Download/Delivery:  9781607610571, 1607610574
Full download Mouse Models for Drug Discovery Methods and Protocols 1st Edition after payment

Product details: 

ISBN 10:   1607610574

ISBN 13: 9781607610571

Author: Michael F.W. Festing, Gabriele Proetzel, Michael V. Wiles

As the drug discovery process shifts more and more toward specifically targeting pathways and molecules, model systems continue to increase in importance, and the mouse, with its versatility, ease of use, and remarkable similarity to the human genome, has clearly risen to the forefront of animal model studies. In Mouse Models for Drug Discovery: Methods and Protocols, experts in the field present some background for those less familiar with mice as experimental model platforms as well as a collection of techniques involving general methods as well as specific disease topics such as type 1 and 2 diabetes, cardiovascular disease, arthritis, skin disorders, cancer, the use of behavioral models for depression and anxiety, neurodegenerative diseases, neuromuscular diseases, and infectious diseases. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easy-to-use, Mouse Models for Drug Discovery: Methods and Protocols will stimulate those not familiar with the power of the mouse and its potential for the drug discovery process, and it will encourage the development of new models and new ways to utilize existing models in order to further the use of this dynamic animal in this vital field.

Table of contents: 

1. Improving Toxicity Screening and Drug Development by Using Genetically Defined Strains

• Michael F.W. Festing

2. The Sophisticated Mouse: Protecting a Precious Reagent

• Michael V. Wiles, Rob A. Taft

3. Genetically Engineered Mouse Models in Drug Discovery Research

• Rosalba Sacca, Sandra J. Engle, Wenning Qin, Jeffrey L. Stock, John D. McNeish

4. Engineering the Mouse Genome to Model Human Disease for Drug Discovery

• Frank Koentgen, Gabriele Suess, Dieter Naf

5. Profiling of Drug Action Using Reporter Mice and Molecular Imaging

• Gianpaolo Rando, Andrea Biserni, Paolo Ciana, Adriana Maggi

6. Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies

• Derry C. Roopenian, Gregory J. Christianson, Thomas J. Sproule

7. Development of Novel Major Histocompatibility Complex Class I and Class II-Deficient NOD-SCID IL2R Gamma Chain Knockout Mice for Modeling Human Xenogeneic Graft-Versus-Host Disease

• Steve Pino, Michael A. Brehm, Laurence Covassin-Barberis, Marie King, Bruce Gott, Thomas H. Chase et al.

8. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans

• David V. Serreze, Marijke Niens, John Kulik, Teresa P. DiLorenzo

9. Mouse Models of Type II Diabetes Mellitus in Drug Discovery

• Helene Baribault

10. Cholesterol Absorption and Metabolism

• Philip N. Howles

11. Collagen-Induced Arthritis in Mice

• Lisette Bevaart, Margriet J. Vervoordeldonk, Paul P. Tak

12. Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening

• John P. Sundberg, Kathleen A. Silva, Caroline McPhee, Lloyd E. King JR

13. Models of Metastasis in Drug Discovery

• James E. Talmadge

14. Methods for Evaluating Effects of an Irinotecan + 5-Fluorouracil/Leucovorin (IFL) Regimen in an Orthotopic Metastatic Colorectal Cancer Model Utilizing In Vivo Bioluminescence Imaging

• David Surguladze, Philipp Steiner, Marie Prewett, James R. Tonra

15. CML Mouse Model in Translational Research

• Cong Peng, Shaoguang Li

16. Mouse Models for Studying Depression-Like States and Antidepressant Drugs

• Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.

17. Virus-Delivered RNA Interference in Mouse Brain to Study Addiction-Related Behaviors

• Amy W. Lasek, Nourredine Azouaou

18. Experimental Models of Anxiety for Drug Discovery and Brain Research

• Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.

19. Mouse Models of Neurodegenerative Diseases: Criteria and General Methodology

• Christopher Janus, Hans Welzl

People also search for:

    
drug release models
    
mouse model drug development
    
mouse derived drugs
    
mouse models of human disease
    
humanized mouse models for immuno-oncology drug discovery

Tags: Michael Festing, Gabriele Proetzel, Michael Wiles, Mouse Models, Drug Discovery Methods