Metal Ions in Biological Systems Volume 40 The Lanthanides and Their Interrelations with Biosystems 1st Edition by Helmut Sigel ISBN 978-0824742454 0824742451

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Product details: 

ISBN 10:  0824742451

ISBN 13: 978-0824742454

Author: Helmut Sigel 

The Metal Ions in Biological Systems series is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Written by 36 internationally recognized experts and enriched with nearly 200 illustrations, Volume 40 highlights fast moving research on lanthanides and their interrelations with biosystems and emphasizes their recent impact in biochemical and biological studies, and in medicine.

Table of contents: 

Chapter 1

DISTRIBUTION OF THE LANTHANIDES IN THE EARTH’S CRUST

Stuart Ross Taylor and Scott M. McLennan

1. Geochemical Behavior of the Lanthanides

2. Lanthanide Mineralogy

3. Samarium-Neodymium and Hafnium-Lutetium Isotope Geochemistry

4. The Oceanic Crust of the Earth

5. The Continental Crust

6. Lanthanides in the Continental Crust

7. Europium as a Geochemical Tracer

Abbreviations and Definitions

References

Chapter 2

MOBILIZATION OF LANTHANIDES THROUGH THE TERRESTRIAL BIOSPHERE

Robert A. Bulman

1. Basic Lanthanide Chemistry

2. Sources of Lanthanides for Environmental Processes

3. Weathering of Rocks: Formation of Soil and Abundance of Lanthanides

4. Microbial Interactions with Lanthanides

5. Uptake of Lanthanides into Plants

6. General Conclusions

Acknowledgments

Abbreviations and Definitions

References

Chapter 3

COMPLEXES OF LANTHANIDE IONS WITH AMINO ACIDS, NUCLEOTIDES, AND OTHER LIGANDS OF BIOLOGICAL INTEREST IN SOLUTION

Herbert B. Silber and Sarah J. Paquette

1. Introduction

2. Results from Complexes with Model Ligands

3. Complexes of Amino Acids with Lanthanide lons

4. Lanthanide Phospholipid Complexes

5. Interactions of Nucleotides and Lanthanide Ions

6. Complexes of Lanthanides with Sugar-Type Ligands

7. Conclusions and Perspectives

Acknowledgments

Abbreviations and Definitions

References

Chapter 4

BIOLOGICALLY RELEVANT STRUCTURAL COORDINATION CHEMISTRY OF SIMPLE

LANTHANIDE ION COMPLEXES

Jack M. Harrowfield

1. Introduction

2. X-Ray Structural Studies of Simple Lanthanide Ion Complexes

3. Summary and Overview

Acknowledgments

Abbreviations

References

Chapter 5

LANTHANIDE IONS AS PROBES IN STUDIES OF METAL ION-DEPENDENT ENZYMES

Etsuro Yoshimura and Tokuko Watanabe

1. Introduction

2. Modulation of Enzyme Activity by Lanthanide Ions and Suitability as Probes

3. Conclusions

4. Appendix: Methodologies

Abbreviations

References

Chapter 6

LANTHANIDE CHELATES AS FLUORESCENCE LABELS FOR DIAGNOSTICS AND BIOTECHNOLOGY

Kazuko Matsumoto and Jingli Yuan

1. Introduction

2. Lanthanide Fluorescent Complexes and Labels

3. Application to Time-Resolved Fluoroimmunoassay

4. Application to DNA Hybridization Assay and Cell

Activity Assay

5. Application to Chromatography

6. Application to Time-Resolved Fluorescence Imaging

7. Conclusions

Abbreviations

References

Chapter 7

RESPONSIVE LUMINESCENT LANTHANIDE COMPLEXES

David Parker and J. A. Gareth Williams

1. Introduction

2. Mechanistic Basis for Mode of Action

3. pH Dependent Luminescence

4. Anion Dependent Luminescence

5. Oxygen Dependent Luminescence

6. Modulation by Metal Ions and Selected Molecules

7. Concluding Remarks

Abbreviations

References

Chapter 8

LANTHANIDE IONS AS PROBES OF ELECTRON TRANSFER IN PROTEINS

Ronald M. Supkowski and William DeW. Horrocks, Jr.

1. Introduction

2. The Parvalbumin/Lanthanide Model System

3. Proof of Electron Transfer in the Model System

4. Application of Markus Theory of Electron Transfer to the Model System

5. Conclusions

Acknowledgments

Abbreviations and Definitions

References

Chapter 9

LANTHANIDE IONS AS LUMINESCENT PROBES OF PROTEINS AND NUCLEIC ACIDS

Claudia Turro, Patty K.-L. Fu, and Patricia M. Bradley

1. Introduction

2. Photophysical Properties of Lanthanides

3. Nucleic Acids

4. Proteins and Enzymes

5. Conclusions

Acknowledgments

Abbreviations

References

Chapter 10

LANTHANIDE-PROMOTED PEPTIDE BOND HYDROLYSIS

Makoto Komiyama and Tohru Takarada

1. Introduction

2. Peptide Hydrolysis by Ce(IV)

3. Activities of Other Lanthanide and Non-Lanthanide lons

4. Mechanism of Peptide Hydrolysis

5. Homogeneous Hydrolysis of Peptides by Lanthanide-Cyclodextrin Complexes

6. Origin of the Remarkable Activity of Ce(IV)

7. Conclusion

Acknowledgments

Abbreviations

References

Chapter 11

LANTHANIDE-CATALYZED HYDROLYSIS OF PHOSPHATE ESTERS AND NUCLEIC ACIDS

Hans-Jörg Schneider and Anatoly K. Yatsimirsky

1. Introduction and Scope

2. Mechanisms of Phosphate Ester Hydrolysis

3. Formation of Lanthanide Complexes in Water and Their Catalytic Use

4. Kinetics of Catalytic Phosphate Ester Hydrolysis

5. Lanthanide Alkoxide and Hydroperoxide Complexes

6. Catalysis with Di- and Polynuclear Complexes

7. Analogs of Functional Amino Acids in Catalytic Centers

8. Other Lanthanide-Based Systems

9. A Final Performance Comparison of Lanthanides with Other Metal Ions

10. Conclusions and Outlook

Acknowledgments

Abbreviations

References

Chapter 12

SEQUENCE-SELECTIVE SCISSION OF DNA AND RNA BY LANTHANIDE IONS AND THEIR COMPLEXES

Makoto Komiyama

1. Significance of Site-Selective Scission of DNA and RNA

2. Molecular Design for a Sequence-Selective Scission

3. Sequence-Selective DNA Cutters (Artificial Restriction Enzymes)

4. Sequence-Selective RNA Cutters (Ribozyme Mimics)

5. Conclusion

Acknowledgments

Abbreviations

References

Chapter 13

LANTHANIDE IONS AS PROBES FOR METAL IONS IN THE STRUCTURE AND CATALYTIC MECHANISM OF RIBOZYMES

Roland K. O. Sigel and Anna Marie Pyle

1. Introduction

2. Using Lanthanides to Study the Catalytic Mechanism of Ribozymes

3. Defining Metal Ion Binding Sites by Lanthanide-Induced Cleavage of the Phosphodiester Backbone

4. X-Ray Crystal Structures of Ribozymes and Lanthanides

5. Conclusions and Possible Future Applications of Lanthanides in Ribozyme Chemistry

Acknowledgments

Abbreviations and Definitions

References

Chapter 14

LANTHANIDES AS SHIFT AND RELAXATION AGENTS IN ELUCIDATING THE STRUCTURE OF PROTEINS AND NUCLEIC ACIDS

Carlos F. G. C. Geraldes and Claudio Luchinat

1. Introduction

2. Lanthanides as Structural Probes

3. Theory of Paramagnetic NMR Effects of Lanthanide lons

4. Stable Lanthanide-Macromolecule Complexes

5. Structural Studies of Proteins in Solution

6. Probing Protein Surfaces and Protein Interactions with Lanthanide Chelates

7. Ln³+ as Probes of Nucleic Acids

8. Conclusions and Perspectives

Acknowledgments

Abbreviations

References

Chapter 15

LANTHANIDE IONS AS MAGNETIC RESONANCE IMAGING AGENTS. NUCLEAR AND ELECTRONIC RELAXATION PROPERTIES. APPLICATIONS

Lothar Helm, Éva Tóth, and André E. Merbach

1. Introduction

2. Physical Principles of Medical Imaging by Nuclear Magnetic Resonance

3. Relaxation Enhancement Induced by Gd(III) Complexes

4. Application: Design of High Relaxivity Agents

5. Conclusions

Acknowledgments

Abbreviations

Structural Formulas of Ligands

References

Chapter 16

INTERACTIONS OF LANTHANIDES AND THEIR COMPLEXES WITH PROTEINS. CONCLUSIONS REGARDING MAGNETIC RESONANCE IMAGING

Silvio Aime, Alessandro Barge, Mauro Botta, and Enzo Terreno

1. Generalities on Magnetic Resonance Imaging and Gd(III)-Based Contrast Agents

2. Interactions of Lanthanide(III) lons with Proteins

3. Interactions of Gadolinium(III) Complexes with Proteins

4. Responsive Systems Based on Protein Binding

5. Concluding Remarks

Acknowledgments

Abbreviations

References

Chapter 17

METABOLISM AND TOXICITY OF THE LANTHANIDES

Robert A. Bulman

1. Introduction

2. Chemistry

3. Sites of Deposition in Animals

4. Routes of Uptake by Man

5. Aspects of Biochemical Behavior and Toxicity

6. General Conclusions

Acknowledgments

Abbreviations

References

Chapter 18

CELL RESPONSES TO LANTHANIDES AND POTENTIAL PHARMACOLOGICAL ACTIONS OF LANTHANIDES

Kui Wang, Yi Cheng, Xiaoda Yang, and Rongchang Li

1. Introduction

2. Biological Effects of Potential Medical Significance

3. Therapeutic Significances of the Biological Effects of Lanthanides

4. Problems to Be Solved

Acknowledgment

Abbreviations

References

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