Medical Biochemistry 4th Edition by N V Bhagavan ISBN 0120954400 9780120954407

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ISBN 10: 0120954400 
ISBN 13: 9780120954407
Author: N V Bhagavan

Thoroughly updated and in a new two-color format, this well- respected text presents the fundamentals of biochemistry and related topics to students pursuing a one- or two-semester course in pre-med biochemistry or medical programs. The second edition is equally applicable to other health-related fields such as clinical chemistry, medical technology or pharmacology. Medical Biochemistry, Fourth Edition, focuses on the foundations and clinically relevant applications of normal human biochemistry and pathology. Abundantly illustrated with four-color plates.

Revised chapters on molecular biology reflect the latest research in the field
Two color throughout with four color plates
Reference quality appendices include practical information on clinical lab parameters used to diagnose a range of diseases

Medical Biochemistry 4th Table of contents:

Part I: Chemical Principles and Biological Molecules

• Chapter 1: The Chemical Basis of Life

  • Water: The Solvent of Life

  • Acids, Bases, and Buffers

  • Biologically Important Ions

• Chapter 2: Amino Acids and Peptides

  • Structure and Classification of Amino Acids

  • Peptide Bonds and Peptides

  • Acid-Base Properties of Amino Acids

• Chapter 3: Proteins: Structure and Function

  • Levels of Protein Structure (Primary, Secondary, Tertiary, Quaternary)

  • Protein Folding and Denaturation

  • Methods for Protein Separation and Characterization

  • Specific Protein Functions (Enzymes, Transport Proteins, Structural Proteins)

• Chapter 4: Enzymes: Catalysis and Regulation

  • Enzyme Nomenclature and Classification

  • Mechanism of Enzyme Action (Active Site, Transition State)

  • Enzyme Kinetics (Michaelis-Menten Equation)

  • Factors Affecting Enzyme Activity (pH, Temperature, Inhibitors)

  • Regulation of Enzyme Activity (Allosteric Control, Covalent Modification)

• Chapter 5: Carbohydrates

  • Monosaccharides, Disaccharides, Polysaccharides

  • Structure and Classification

  • Glycosidic Bonds

  • Biologically Important Carbohydrates (Glycogen, Starch, Cellulose)

• Chapter 6: Lipids and Biological Membranes

  • Fatty Acids, Triacylglycerols, Phospholipids, Steroids

  • Structure and Classification of Lipids

  • Properties of Biological Membranes (Fluid Mosaic Model)

  • Membrane Proteins and Transport Systems

• Chapter 7: Nucleic Acids and Nucleotides

  • Structure of DNA and RNA

  • Nucleotides and Nucleosides

  • Functions of Nucleotides (ATP, cAMP, NAD+, FAD)

Part II: Energy Metabolism

• Chapter 8: Bioenergetics and Oxidative Phosphorylation

  • Laws of Thermodynamics in Biological Systems

  • ATP: The Energy Currency

  • Electron Transport Chain

  • Chemiosmotic Theory

• Chapter 9: Carbohydrate Metabolism I: Glycolysis, Glycogen Metabolism, and Hexose Monophosphate Shunt

  • Glycolysis Pathway and Regulation

  • Gluconeogenesis

  • Glycogen Synthesis and Degradation

  • Hexose Monophosphate Shunt (Pentose Phosphate Pathway)

• Chapter 10: Carbohydrate Metabolism II: The Citric Acid Cycle and Oxidative Metabolism

  • Pyruvate Dehydrogenase Complex

  • Citric Acid Cycle (Krebs Cycle)

  • Integration of Metabolic Pathways

• Chapter 11: Lipid Metabolism I: Digestion, Absorption, and Transport

  • Digestion and Absorption of Dietary Lipids

  • Lipoprotein Metabolism (Chylomicrons, VLDL, LDL, HDL)

• Chapter 12: Lipid Metabolism II: Fatty Acid Synthesis and Degradation

  • Beta-Oxidation of Fatty Acids

  • Fatty Acid Synthesis (Lipogenesis)

  • Ketone Body Metabolism

• Chapter 13: Lipid Metabolism III: Cholesterol and Steroid Metabolism

  • Cholesterol Synthesis and Regulation

  • Bile Acid Synthesis

  • Steroid Hormone Synthesis

• Chapter 14: Amino Acid Metabolism

  • Overview of Protein Digestion and Amino Acid Pool

  • Transamination and Deamination

  • Urea Cycle

  • Metabolism of Individual Amino Acids (Glucogenic, Ketogenic)

• Chapter 15: Nucleotide Metabolism

  • Purine and Pyrimidine Synthesis (De Novo and Salvage Pathways)

  • Degradation of Purines and Pyrimidines

  • Disorders of Nucleotide Metabolism (e.g., Gout)

Part III: Molecular Biology and Information Transfer

• Chapter 16: DNA Replication, Repair, and Recombination

  • Structure of DNA and Chromosomes

  • DNA Replication Mechanisms

  • DNA Repair Pathways

  • Genetic Recombination

• Chapter 17: RNA Synthesis and Processing (Transcription)

  • Types of RNA (mRNA, tRNA, rRNA)

  • Mechanism of Transcription

  • RNA Processing (Splicing, Capping, Polyadenylation)

• Chapter 18: Protein Synthesis (Translation)

  • The Genetic Code

  • Ribosomes and tRNA

  • Steps of Protein Synthesis (Initiation, Elongation, Termination)

  • Post-Translational Modifications

• Chapter 19: Regulation of Gene Expression

  • Prokaryotic Gene Regulation (Operons)

  • Eukaryotic Gene Regulation (Transcription Factors, Chromatin Remodeling)

• Chapter 20: Recombinant DNA Technology and Biotechnology

  • Restriction Enzymes and DNA Cloning

  • PCR (Polymerase Chain Reaction)

  • DNA Sequencing

  • Gene Therapy

  • Applications in Medicine and Research

Part IV: Specialized Tissues and Clinical Applications

• Chapter 21: Biochemistry of Hormones

  • Classification of Hormones

  • Mechanism of Hormone Action (Receptors, Signal Transduction)

  • Major Endocrine Glands and Their Hormones

• Chapter 22: Biochemistry of Digestion and Absorption

  • Role of Digestive Enzymes

  • Absorption of Nutrients

• Chapter 23: Liver Metabolism

  • Central Role of the Liver in Metabolism

  • Detoxification and Biotransformation

  • Liver Function Tests

• Chapter 24: Muscle Contraction and Metabolism

  • Structure of Muscle

  • Mechanism of Muscle Contraction

  • Energy Sources for Muscle Activity

• Chapter 25: Connective Tissue: Collagen, Elastin, and Proteoglycans

  • Structure and Synthesis of Connective Tissue Components

  • Disorders of Connective Tissue

• Chapter 26: Biochemistry of Blood and Immunology

  • Components of Blood Plasma and Cells

  • Hemoglobin Structure and Function

  • Blood Coagulation

  • Basic Principles of Immunology

• Chapter 27: Biochemistry of the Nervous System

  • Neurotransmitters and Their Receptors

  • Signal Transduction in Neurons

  • Myelin and Demyelination

• Chapter 28: Nutrition and Nutritional Disorders

  • Dietary Guidelines

  • Vitamin and Mineral Deficiencies

  • Obesity and Metabolic Syndrome

  • Eating Disorders

• Chapter 29: Cancer Biochemistry

  • Molecular Basis of Cancer

  • Oncogenes and Tumor Suppressor Genes

  • Apoptosis

  • Biochemical Approaches to Cancer Therapy

• Chapter 30: Clinical Chemistry and Diagnostic Tests

  • Common Biochemical Tests (Blood Glucose, Liver Enzymes, Kidney Function Tests)

  • Interpretation of Lab Results

  • Biomarkers of Disease

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Tags: N V Bhagavan, Medical, Biochemistry