Lu s basic toxicology 4ed Edition by Lu, Kacew ISBN 9780415248556 0415248558

Lu s basic toxicology 4ed Edition by Lu F.C., Kacew S.   – Ebook PDF Instant Download/Delivery: 9780415248556, 0415248558
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Product details: 

ISBN 10: 0415248558

ISBN 13: 9780415248556

Author: Lu F.C., Kacew S.  

Complete syllabus material: Lu s basic toxicology 4ed Edition Lu F.C.Available now. Covers essential areas of study with clarity, detail, and educational integrity.

Table of contents: 

PART I – General Principles of Toxicology

1. General Considerations
1.1 Definition and Purpose of Toxicology
1.2 Scope and Subdisciplines
1.3 Early Developments
1.4 Recent Developments
1.5 Some Challenges and Successes
1.6 Toxicity vs. Other Considerations
1.7 Future Prospects
1.8 References
1.9 Appendix 1.1: U.S. Laws That Have a Basis in Toxicology
1.10 Appendix 1.2: Examples of Outbreaks of Mass Poisoning

2. Absorption, Distribution, and Excretion of Toxicants
2.1 Introduction
2.2 Absorption
2.3 Distribution
2.4 Excretion
2.5 Levels of Toxicants in the Body
2.6 References

3. Biotransformation of Toxicants
3.1 Bioactivation
3.2 Complex Nature of Biotransformation
3.3 References
3.4 Appendix 3.1: Examples of Bioactivation

4. Toxic Effects
4.1 General Considerations
4.2 Spectrum of Toxic Effects
4.3 Target Organs
4.4 Mechanisms of Action
4.5 Molecular Targets: Chemical Nature
4.6 Receptors
4.7 References

5. Modifying Factors of Toxic Effects
5.1 General Considerations
5.2 Host Factors
5.3 Environmental Factors
5.4 Chemical Interaction
5.5 References
5.6 Appendix 5.1: Mechanisms Underlying Certain Modifying Factors
5.7 Appendix 5.2: Strain-Related Differences in Drug-Induced Responses

PART II – Testing Procedures for Conventional and Nontarget Organ Toxicities

6. Conventional Toxicity Studies
6.1 Introduction
6.2 Acute Toxicity Studies
6.3 Short-Term and Long-Term Toxicity Studies
6.4 Good Laboratory Practice
6.5 References
6.6 Additional Reading
6.7 Appendix 6.1: General Observations, Clinical Laboratory Tests, and Pathology Examinations Used in Short- and Long-Term Toxicity Studies

7. Carcinogenesis
7.1 Introduction
7.2 Mode of Action
7.3 Categories of Carcinogens
7.4 Some Human Carcinogens/Target Organs
7.5 Tests for Carcinogenicity
7.6 Evaluation
7.7 References
7.8 Additional Reading
7.9 Appendix 7.1: Probable Carcinogenic Chemicals
7.10 Appendix 7.2: Biomarkers of Carcinogenesis/Human Cancers

8. Mutagenesis
8.1 Introduction
8.2 Gene Mutation
8.3 Chromosomal Effects
8.4 DNA Repair and Recombination
8.5 Other Tests
8.6 Evaluation
8.7 References

9. Developmental Toxicology
9.1 Introduction
9.2 Teratogens (Developmental Toxicants) and Their Effects
9.3 Mode of Action
9.4 Teratogens of Special Interest
9.5 Testing Procedures
9.6 Evaluation of Teratogenic Effects
9.7 References
9.8 Appendix 9.1: Teratogens in Animal Models

10. Lactation
10.1 General Remarks
10.2 Benefits of Breast-Feeding
10.3 Toxicants
10.4 References

PART III – Target Organs and Systems

11. Toxicology of the Immune System
11.1 General Considerations
11.2 Components of the System
11.3 Immunotoxicants
11.4 Immunotoxicities: Testing Procedures
11.5 Evaluation
11.6 References
11.7 Additional Reading

12. Respiratory System: Inhalation Toxicology
12.1 Introduction
12.2 Toxicants and Their Effects
12.3 Testing Procedures
12.4 Evaluation
12.5 References
12.6 Appendix 12.1: Site of Action and Pulmonary Disease Produced by Selected Occupationally Inhaled Toxicants
12.7 Appendix 12.2: Mechanisms Underlying the Oxidative Stress Induced by Cigarette Smoke

13. Toxicology of the Liver
13.1 General Considerations
13.2 Types of Liver Injury
13.3 Hepatotoxicants
13.4 Testing Procedures
13.5 Evaluation
13.6 References
13.7 Appendix 13.1: Examples of Hepatotoxic Agents and Associated Liver Injury

14. Toxicology of the Kidney
14.1 Introduction
14.2 Nephrotoxicants: Mechanism and Site of Action
14.3 Testing Procedure
14.4 Evaluation
14.5 References
14.6 Additional Reading

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