Kinomics Approaches and Applications 1st Edition by Heinz-Bernhard Kraatz, Sanela Martic ISBN 978-3527337651 3527337652

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Product details: 

ISBN 10:   3527337652

ISBN 13: 978-3527337651

Author:  Heinz-Bernhard Kraatz,  Sanela Martic  
Authored by the world’s leading kinase experts, this is a comprehensive introduction to current knowledge and practice within this emerging field.
Following an overview of the major players and pathways that define the kinome, the major part of this work is devoted to current strategies of kinome investigation and manipulation. As such, kinase engineering, peptide substrate engineering, co-substrate design and kinase inhibitor design are discussed in detail, and their potential applications in kinome analysis and kinome-based pharmacotherapy are shown.
The result is a toolbox for every kinase researcher: By addressing and comparing current approaches to the study of kinase action, both novice and established researchers will benefit from the practical knowledge contained in this invaluable reference.

Table of contents: 

Part I: Protein Kinases and Cellular Signaling
Chapter 1. Global Overview of Protein Kinase Function

A brief history of the human kinome

Kinase groups: AGC, CaMK, CMGC, STE, Tyrosine, Casein, TK-like, RGC, Atypical

Roles in diseases: neurodegeneration, cancer

Research methods: mass spectrometry, FRET, in vitro/in vivo, CRISPR

Chapter 2. The “Real” Casein Kinase (Fam20C): Mother of the Phosphosecretome

Discovery and characteristics of Fam20C

Mechanism and regulation

Potential role in phosphate homeostasis and disease therapy

Chapter 3. Chemical Biology of Protein Kinases

Chemical genetic basis

Analog-sensitive kinases (AS kinases)

Substrate and inhibitor identification

Chapter 4. Bidirectional Crosstalk Between Kinases and Caspases in Apoptosis

Apoptotic pathways

Mechanisms of kinase–caspase crosstalk

Experimental strategies and implications

Chapter 5. Kinomics in Malaria Research

The Plasmodium kinome

Phosphoproteomics and phosphorylation pathways

Host kinase modulation and drug development

Part II: ATP Cosubstrate Design
Chapter 6. ATP Analogs in Protein Kinase Research

Modifications to base, sugar, and phosphate groups

Applications in kinase studies

Chapter 7. Electrochemical Detection of Kinase-Catalyzed Phosphorylation

Label-free and labeled methods

Use of electrochemical cosubstrates like ferrocene–ATP

Part III: Emerging Methods in Kinomics
Chapter 8. Phos-tag Technology in Kinomics

Principles and applications of Phos-tag

Phosphoprotein detection by blotting and electrophoresis

Chapter 9. Species- and Process-Specific Kinome Peptide Arrays

Design of species-specific peptide arrays

Applications in infectious diseases (human, livestock, bees)

Chapter 10. Emerging Methods for Studying Bacterial Histidine Kinase Activity and Inhibition

Two-component signal transduction systems

HK research techniques and drug targeting strategies

Chapter 11. High-Throughput Methods for Mapping Kinase Substrate Networks

Computational prediction

Mass spectrometry, analog-sensitive kinases, arrays, and solution-phase assays

Part IV: Kinase Inhibition
Chapter 12. Targeting STAT3: A Post-Kinase Strategy for Disease Therapy

STAT3 structure and signaling

Direct inhibition: peptides, small molecules, oligonucleotides

Chapter 13. Metal-Based Compounds as Kinase and Phosphatase Inhibitors in Drug Development

Geometric advantages of metal complexes

Applications in cancer therapy and phosphatase inhibition (e.g., vanadium)

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Tags: Heinz-Bernhard Kraatz, Sanela Martic, Kinomics Approaches