Human Molecular Genetics Fourth Edition by Tom Strachan ISBN 978-0815341499 0815341490
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Product details:
ISBN 10: 0815341490
ISBN 13: 978-0815341499
Author: Tom Strachan
Following the completion of the Human Genome Project the content and organization of the third edition of Human Molecular Genetics (HMG) has been thoroughly revised. PART ONE (CHAPTERS 1-7) covers basic material on DNA structure and function, chromosomes, cells and development, pedigree analysis and the basic techniques used in the laboratory. PART TWO (CHAPTERS 8-12) discusses the various genome sequencing projects and the insights they provide into the organization, expression, variation and evolution of our genome. PART THREE (CHAPTERS 13-18) focuses on mapping, identifying and diagnosing the genetic causes of mendelian and complex diseases and cancer. PART FOUR (CHAPTERS (19-21) looks at the wider horizons of functional genomics, proteomics, bioinformatics, animal models and therapy. There are new chapters on cells and development and on functional genomics. The sections on complex diseases have been completely rewritten and reorganized, as has the chapter on Genome Projects. Other changes include a new section on molecular phylogenetics (Chapter 12) and the introduction of ‘Ethics Boxes’ to discuss some of the implications of the new knowledge. Virtually every page has been revised and updated to take account of the stunning developments of the past four years since the publication of the last edition of Human Molecular Genetics.
Table of contents:
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Nucleic Acid Structure and Gene Expression
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Chromosome Structure and Function
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Genes in Pedigrees and Populations
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Cells and Cell–Cell Communication
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Principles of Development
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Amplifying DNA: Cell-Based DNA Cloning and PCR
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Nucleic Acid Hybridization: Principles and Applications
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Analyzing the Structure and Expression of Genes and Genomes
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Organization of the Human Genome
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Model Organisms, Comparative Genomics, and Evolution
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Human Gene Expression
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Studying Gene Function in the Post-Genome Era
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Human Genetic Variability and Its Consequences
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Genetic Mapping of Mendelian Characters
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Mapping Genes Conferring Susceptibility to Complex Diseases
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Identifying Human Disease Genes and Susceptibility Factors
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Cancer Genetics
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Genetic Testing of Individuals
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Pharmacogenetics, Personalized Medicine, and Population Screening
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Genetic Manipulation of Animals for Modeling Disease and Investigating Gene Function
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Genetic Approaches to Treating Disease
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