Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Cancer Drug Discovery and Development 1st Edition by William Figg, Howard McLeod ISBN 978-1592597345 1592597345

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Cancer Drug Discovery and Development 1st Edition by William D. Figg, Howard L. McLeod – Ebook PDF Instant Download/Delivery: 978-1592597345, 1592597345
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Product details: 

ISBN 10:  1592597345

ISBN 13: 978-1592597345

Author:  William D. Figg, Howard L. McLeod 

Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.

Table of contents: 

1. Molecular Targets
2. Preclinical Screening for New Anticancer Agents
3. Mouse Models in Cancer Drug Discovery and Development
4. Defining the Starting Dose
5. Phase I Trials in Oncology
6. Analytical Methods
7. Validation and Control of Bioanalytical Methods in Clinical Drug Development
8. Clinical Pharmacology Overview
9. Pharmacokinetic Modeling
10. Pharmacodynamic Modeling
11. Pharmacometric Knowledge-Based Oncology Drug Development
12. Protein Binding of Anticancer Drugs
13. Metabolism (Non-CYP Enzymes)
14. Cytochrome P450 and Anticancer Drugs
15. Polymorphisms in Genes of Drug Targets and Metabolism and in DNA Repair
16. Drug Interactions
17. ABC Transporters
18. Intrathecal Chemotherapy
19. Use of Microdialysis in Preclinical and Clinical Development of Anticancer Agents
20. Regional Therapy of Cancer Using Continuous Hyperthermic Peritoneal Perfusion or Vascular Isolation and Perfusion Techniques
21. Isolated Lung Perfusion for the Treatment of Inoperable Pulmonary Malignancies
22. Pharmacokinetics of Isolated Lung Perfusion with Antitumor Agents
23. Central Nervous System Malignancy and Clinical Pharmacology
24. Pharmacokinetics of Anticancer Drugs in Children
25. Clinical Pharmacokinetics in the Elderly
26. The Combination of Angiogenesis Inhibitors and Radiotherapy for the Treatment of Primary Tumors
27. Gene Therapy for the Treatment of Cancer
28. Vaccines for the Treatment of Cancer
29. Pharmacokinetics of Antibodies and Immunotoxins in Mice and Humans
30. Pharmacokinetics of Biologicals
31. Exposure-Response Relationship of Anticancer Agents
32. Identifying Agents to Test in Phase III Trials
33. Clinical Trial Designs for Approval of New Anticancer Agents
34. Pharmacogenetic Counseling

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Tags: William Figg, Howard McLeod, Handbook of Anticancer, Pharmacokinetics and Pharmacodynamics