Genetic Analysis of Complex Disease 2nd Edition by Jonathan Haines ISBN 9780471781134 0471781134
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Product details:
ISBN 10: 0471781134
ISBN 13: 9780471781134
Author: Jonathan L. Haines
JONATHAN L. HAINES is Director of the Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine. His research into the localization and identification of genes involved in human disease includes studying Alzheimer’s disease, multiple sclerosis, Parkinson’s disease, autism, macular degeneration, and other complex diseases.
MARGARET A. PERICAK-VANCE is Director of the Center for Human Genetics and Chief of the Section of Medical Genetics in the Department of Medicine, Duke University School of Medicine. She is a founding Fellow of the American College of Medical Genetics. Her research interests include the integration of genomic and statistical technologies and their application to diseases of importance to public health, with an emphasis on neurologic diseases.
Table of contents:
1. Basic Concepts in Genetics and Linkage Analysis
2. Defining Disease Phenotypes
3. Determining Genetic Component of a Disease
4. Patient and Family Participation in Genetic Research Studies
5. Collection of Biological Samples for DNA Analysis
6. Methods of Genotyping
7. Data Analysis Issues in Expression Profiling
8. Information Management
9. Quantitative Trait Linkage Analysis
10. Advanced Parametric Linkage Analysis
11. Nonparametric Linkage Analysis
12. Linkage Disequilibrium and Association Analysis
13. Sample Size and Power
14. Complex Genetic Interactions
15. Genomics and Bioinformatics
16. Designing a Study for Identifying Genes in Complex Traits
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