Extracellular Matrix in Development and Disease 1st Edition by Jeffrey Miner ISBN 978-0444518460 0444518460
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Product details:
ISBN 10: 0444518460
ISBN 13: 978-0444518460
Author: Jeffrey H. Miner
Extracellular matrix proteins are serious, common human diseases that are caused by mutations in genes that encode these proteins. This has spurred a great number of researchers to study the extracellular matrix, sometimes by choice and sometimes by necessity. Much progress has been made in the last decade towards understanding what matrix proteins do and how cells interact with and respond to them. Volume 15 is a compilation of reviews by experts in their respective fields. The chapters in this book address the biology of a broad spectrum of extracellular matrix molecules and their functions in development and disease. This book has been designed to focus on a diverse subset of matrix proteins that have been shown to be important for development, function, and disease. The book therefore both presents a broad view of the field and provides crucial details about some of the best-studied matrix molecules.
* Written by leaders in the field* Discusses the potential of matrix components to be used as therapeutic tools for the treatment and prevention of cancer* Offers a section on integrin signaling and the development of the central nervous system, detailing the migration of neurons and the glia* Covers a diverse array of molecules such as laminins, collagens, heparan sulfate proteoglycans, integrins, and more
Table of contents:
1. Introduction
2. Basement membranes
2.1. Structure
2.2. Molecular composition
2.3. Function
3. Type IV collagen genes
3.1. Organization.
3.2. Evolutionary history
3.3. Comparison to other collagen genes
3.4. Transcriptional regulation.
4. Type IV collagen a chains
4.1. Domain structure
4.2. Post-translational modification
5. Type IV collagen protomers.
5.1. Biosynthesis
5.2. Isoform composition.
6. Type IV collagen networks
6.1. Supramolecular assembly
6.2. Distribution
7. Type IV collagen in development: Lessons from invertebrates
7.1. Hydra.
7.2. Sea urchin
7.3. Nematodes
7.4. Drosophila
8. Type IV collagen in development: Lessons from vertebrates
8.1. The al/a2 network in mouse embryogenesis
8.2. The 23/24/25 and a1/a2/a5/a6 networks in fetal and
postnatal development.
8.3. Alport syndrome.
9. Conclusions.
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Tags: Jeffrey Miner, Extracellular Matrix, Development and Disease