Essentials of Pharmaceutical Chemistry 3 3rd Edition by Cairns Donald ISBN 0853697450 978-0071417983

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Product details: 

ISBN 10:  0853697450 

ISBN 13: 978-0071417983

Author:  Cairns Donald

It covers the core information required by pharmacy students to understand the action of modern drugs on the human body.The third edition is larger than the previous edition and includes a new chapter on licensing of drugs and medicines which describes the make up and function of important committees such as the Commission of Human Medicines and the British Pharmacopoeia Commission. This includes material that is within the public domain and explains the process of getting a drug to market.The majority of the chapters include more worked examples/tutorial examples and the chapter on Analytical spectroscopy has been updated to include “qualitative” spectroscopic methods especially NMR, mass spectroscopy and some IR and the chapter on Stability of drugs and medicines has been updated to include a major section on “prodrugs” which are inactive compounds designed to decompose within the body to release the active moiety.

Table of contents: 

1 Chemistry of acids and bases
2 Dissociation of weak acids and bases
3 Hydrolysis of salts
4 Amphiprotic salts
5 Buffer solutions
6 Buffer capacity
7 Biological buffers
8 Ionisation of drugs
9 PK values of drug molecules
10 pH indicators
11 Tutorial examples
12 Problems
13 Partition coefficient and biopharmacy
14 Experimental measurement of partition coefficient
15 Drug absorption, distribution and bioavailability
16 Passive diffusion
17 The pH partition hypothesis
18 Active transport mechanisms
19 The action of local anaesthetics
20 Excretion and reabsorption of drugs
21 Food and drink
22 Tutorial examples
23 Problems
24 Physicochemical properties of drugs
25 Carboxylic acids
26 Phenols
27 Warfarin
28 Phenylbutazone
29 Indomethacin
30 Barbiturates
31 Phenytoin
32 Sulfonamides
33 Basic drugs
34 Basicity of heterocyclic compounds
35 Separation of mixtures
36 Tutorial examples
37 Problems
38 Stereochemistry
39 Polarimetry
40 Biological systems
41 Fischer projections
42 Stereochemistry case study: thalidomide
43 Geometrical isomerism
44 Tutorial examples
45 Problems
46 Drug metabolism
47 Metabolic pathways
48 Cytochromes P450
49 Enzyme induction and inhibition
50 Drug conjugation reactions (Phase 2)
51 Stereochemistry
52 Metabolic pathways for common drugs
53 Tutorial example
54 Problems
55 Volumetric analysis of drugs
56 Volumetric flask
57 Pipette
58 Burettes
59 Units of concentration

60 Analytical spectroscopy
61 Concentration of active ingredients
62 Design of an assay
63 Practical points
64 Back and blank titrations
65 Assay of unit-dose medicines
66 Non-aqueous titrations
67 REDOX titrations
68 Compleximetric titrations
69 Argentimetric titrations
70 Limit tests
71 Problems
72 Effect of pH on spectra
73 Instrumentation
74 Experimental measurement of absorbance
75 Dilutions
76 Quantitative aspects of spectroscopy
77 Beer’s and Lambert’s laws
78 Methods of drug assay
79 Derivative spectroscopy
80 Infrared spectroscopy
81 Fluorimetry
82 Structure elucidation
83 Tutorial examples
84 Problems
85 Stability of drugs and medicines
86 Oxidation
87 Stability of free radicals
88 Prevention of oxidative deterioration
89 Autoxidation of fats and oils
90 Ageing
91 Hydrolysis
92 Examples of drugs susceptible to hydrolysis
93 Other mechanisms of degradation
94 Prodrugs
95 Tutorial examples
96 Problems

97 Kinetics of drug stability
98 Rate, order and molecularity
99 Rate equations and first-order reactions
100 Half-life
101 Shelf-life
102 Second-order reactions
103 Zero-order reactions
104 Reaction rates and temperature
105 Tutorial example
106 Problems
107 Licensing of drugs and the British Pharmacopoeia
108 Structure of the MHRA
109 European licensing procedures
110 Applications for Marketing Authorisations
111 British Pharmacopoeia Commission
112 The British Pharmacopoeia
113 Answers to problems
114 Selected bibliography

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