Drug Monitoring and Clinical Chemistry 1st Edition by Georg Hempel ISBN 978-0444509727 0444509727
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Product details:
ISBN 10: 0444509727
ISBN 13: 978-0444509727
Author: Georg Hempel
Drug Monitoring and Clinical Chemistry (1st Edition, ed. Georg Hempel, 2004) is part of the Handbook of Analytical Separations series. The book provides a comprehensive overview of therapeutic drug monitoring (TDM) and the analytical techniques used in clinical chemistry for measuring drugs in biological fluids. It covers sample preparation, chromatographic and electrophoretic methods, immunoassays, validation of bioanalytical methods, and the clinical interpretation of monitoring results, with applications in pharmacokinetics and individualized therapy, including cancer treatment.
Table of contents:
1. Sample Preparation for the Analysis of Drugs in Biological Fluids
Yoshihiro Saito, Makiko Hayashida, Kiyokatsu Jinno
2. Chromatographic Methods for the Analysis of Drugs in Biological Fluids
Hassan Y. Aboul-Enein, Mohamed M. Hefnawy, Kenichiro Nakashima
3. Capillary Electrophoresis for the Determination of Drugs in Biological Fluids
Zakariya K. Shihabi
4. Immunoassays for Therapeutic Drug Monitoring and Clinical Toxicology
William Clarke
5. Validation of Bioanalytical Methods
S. Berthier
6. Pharmacokinetic Methods for Analysis, Interpretation, and Management of TDM Data, and for Individualizing Drug Dosage Regimens Optimally
Roger Jelliffe, Alan Schumitzky, David Bayard, Michael Van Guilder, Michael Neely
7. Dose and Therapy Individualisation in Cancer Chemotherapy
Georg Hempel
8. Rationale and Utility of Therapeutic Drug Monitoring for the Optimization of Antibiotic Therapy
Christine T. Ong, David P. Nicolau
9. Therapeutic Drug Monitoring of Antiepileptic Drugs
Svein I. Johannessen
10. Therapeutic Drug Monitoring of Antidepressant and Antipsychotic Drugs
Philip B. Mitchell
11. Monitoring Immunosuppressive Drugs
David W. Holt, Atholl Johnston
12. Pharmacogenomics: Methodologies for Genotyping and Phenotyping
Paul J. Jannetto, Elvan Laleli-Sahin, Steven H. Wong
13. Applications of Genotyping and Phenotyping for Clinically-Relevant Polymorphisms of Drug Metabolizing Enzymes and Drug Transporters
Andreas Lazar, Dorota Tomalik-Scharte, Uwe Fuhr
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