Do seizures damage the brain 1st Edition by Thomas Sutula, Pitkänen ISBN 978-0444508140 0444508147

Do seizures damage the brain 1st Edition by Thomas Sutula,  A. Pitkänen – Ebook PDF Instant Download/Delivery: 978-0444508140, 0444508147
Full download Do seizures damage the brain 1st Edition after payment

Product details: 

ISBN 10: 0444508147

ISBN 13: 978-0444508140

Author:  Thomas Sutula,  A. Pitkänen

What are the consequences, if any, of repeated brief seizures that are the defining feature of epilepsy? A firm answer to this question has been surprisingly elusive for a variety of reasons. Clearly there is a subset of patients who appear to tolerate seizures with relatively limited long-term consequences, and not all patients are destined to progress to intractability with frequent seizures and disability. This variability and individual susceptibility has made it difficult to make statements that fairly apply to the full range of people with epileptic disorders, whose disorders span a broad spectrum from mild with excellent control and few limitations, to severe with multiple daily seizures and pronounced disability that affects employment, educational performance, an personal life.

This volume seeks to explore the spectrum of severe to more subtle damage that may be a consequence of seizures. The contributing authors have addressed these questions and related issues using a variety of methods in experimental models and in patients with epilepsy.

Table of contents: 

Section I. Seizure-induced damage in experimental epilepsy
1 Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives – B.S. Meldrum
2 Are seizures harmful: what can we learn from animal models? – A.J. Cole, S. Koh, Y. Zheng
3 Doubt and certainty in counting – R.W. Guillery, B.K. August
4 Design-based stereological methods for counting neurons – M.J. West
5 The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus – F.E. Dudek, J.L. Hellier, P.A. Williams, D.J. Ferraro, K.J. Staley
6 Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy – A. Pitkanen, J. Nissinen, J. Nairismagi, K. Lukasiuk, O.H.J. Grohn, R. Miettinen, R. Kauppinen
7 Does convulsive status epilepticus (SE) result in cerebral damage or affect the course of epilepsy–the epidemiological and clinical evidence? – S. Shorvon
8 Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits – R. Kotloski, M. Lynch, S. Lauersdorf, T. Sutula
9 Neuronal apoptosis after brief and prolonged seizures – J. Bengzon, P. Mohapel, C. Ekdahl, O. Lindvall
10 Seizure-induced neurogenesis: are more new neurons good for an adult brain? – J.M. Parent, D.H. Lowenstein
11 Summary: Seizure-induced damage in experimental models – T. Sutula, A. Pitkanen

Section II. Mechanisms of seizure-induced damage
12 Complications associated with genetic background effects in models of experimental epilepsy – P.E. Schauwecker
13 Genomics and neurological phenotypes: applications for seizure-induced damage – J.A. Del Rio, C. Barlow
14 Functional genomics in experimental and human temporal lobe epilepsy – A.J. Becker, O.D. Wiestler, I. Blumcke
15 What synaptic lipid signaling tells us about seizure-induced damage and epileptogenesis – N.G. Bazan, B. Tu, E.B. Rodriguez de Turco
16 The role of mitochondria and oxidative stress in neuronal damage after brief and prolonged seizures – H.R. Cock
17 Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus – U. Heinemann, K. Buchheim, S. Gabriel, O. Kann, R. Kovacs, S. Schuchmann
18 Summary: Mechanisms of seizure-induced damage – T. Sutula, A. Pitkanen

Section III. Evidence for seizure-induced damage in human studies: epidemiology, pathology, imaging and clinical studies
19 Do seizures beget seizures? – W.A. Hauser, J.R. Lee
20 Do occasional brief seizures cause detectable clinical consequences? – S. Shinnar, W.A. Hauser
21 Hippocampal neuron damage in human epilepsy: Meyer’s hypothesis revisited – G.W. Mathern, P.D. Adelson, L.D. Cahan, J.P. Leite
22 MRI studies. Do seizures damage the brain? – J.S. Duncan
23 Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions – D.V. Lewis, D. Barboriak, J.R. MacFall, J.M. Provenzale, T.V. Mitchell, K.E. VanLandingham
24 Do recurrent seizures cause neuronal damage? A series of studies with MRI volumetry in adults with partial epilepsy – R. Kalviainen, T. Salmenpera
25 Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy – A. Bernasconi, E. Tasch, F. Cendes, L.M. Li, D.L. Arnold
26 Neuroimaging and the progression of epilepsy – W.H. Theodore, W.D. Gaillard
27 Summary: Evidence for seizure-induced damage in human studies: epidemiology, pathology, imaging, and clinical studies – T. Sutula, A. Pitkanen

Section IV. Seizure-induced cell death in development and functional consequences
28 Seizure-induced damage in the developing human: relevance of experimental models – G.L. Holmes, R. Khazipov, Y. Ben-Ari
29 Seizure-induced neuronal death in the immature brain – C.G. Wasterlain, J. Niquet, K.W. Thompson, H. Liu, R. Sankar, A.M. Mazarati, D. Naylor, H. Katsumori, L. Suchomelova, Y. Shirasaka
30 Effects of brief seizures during development – L. Velisek, S.L. Moshe
31 Is neuronal death required for seizure-induced epileptogenesis in the immature brain? – T.Z. Baram, M. Eghbal-Ahmadi, R.A. Bender
32 Assessing the behavioral and cognitive effects of seizures on the developing brain – C.E. Stafstrom
33 Recent experimental studies of the effects of seizures on brain development – J.W. Swann
34 Summary: Seizure-induced damage in development and functional consequences – T. Sutula, A. Pitkanen

Section V. Neuropsychological consequences of human epilepsy
35 Progressive cognitive decline in adolescents and adults with epilepsy – C.B. Dodrill
36 Progressive cognitive decline in epilepsy: an indication of ongoing plasticity – H. Stefan, E. Pauli
37 Progressive behavioral changes in children with epilepsy – J.K. Austin, D.W. Dunn
38 The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function and the risk of progressive cognitive effects – B.P. Hermann, M. Seidenberg, B. Bell
39 Effects of chronic epilepsy on declarative memory systems – C. Helmstaedter
40 Effects of chronic epilepsy on intellectual functions – H. Jokeit, A. Ebner
41 Summary: Neuropsychological consequences of human epilepsy – T. Sutula, A. Pitkanen

Section VI. Implications for management
42 Will brain damage after status epilepticus be history in 2010? – D.M. Treiman
43 Is complete seizure control imperative? – F. Andermann
44 Implications for neuroprotective treatments – B.S. Meldrum
45 Development of neuroprotective compounds in the pharmaceutical industry: Where are we, and where are we going? – N. Santilli
46 So what can we conclude–do seizures damage the brain? – J. Engel Jr.
47 Summary: Implications for management – T. Sutula, A. Pitkanen

People also search for:

do absence seizures cause brain damage
    
do seizures affect a dog’s lifespan
    
do seizures affect appetite
    
do seizures hurt a dog
    
do seizures hurt animals

Tags: Thomas Sutula, Pitkänen, Do seizures, the brain