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DNA Interactions with Polymers and Surfactants 1st Edition by Rita S Dias, Bjorn Lindman ISBN 0470286350 9780470286357

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DNA Interactions with Polymers and Surfactants 1st Edition Rita S. Dias And Björn Lindman Digital Instant Download

Author(s): Rita S. Dias and Björn Lindman
ISBN(s): 9780470286357, 0470286350
Edition: 1
File Details: PDF, 6.22 MB
Year: 2008
Language: english
SKU: EB-1933556 Category: Tag:

DNA Interactions with Polymers and Surfactants 1st Edition by Rita S Dias, Bjorn Lindman – Ebook PDF Instant Download/Delivery: 0470286350, 9780470286357
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Product details:

ISBN 10: 0470286350 
ISBN 13: 9780470286357
Author: Rita S Dias, Bjorn Lindman

Due to the potential benefits of biotechnology, interest in the interaction between DNA and surfactants and polymers has become increasingly significant. Now, DNA Interactions with Polymers and Surfactants provides an extensive, up-to-date overview of the subject, giving readers a basis for understanding the factors leading to complexation between DNA and different cosolutes, including metal ions, polyelectrolytes, spermine, spermidine, surfactants and lipids, and proteins.

DNA Interactions with Polymers and Surfactants 1st Table of contents:

Part I: Fundamental Concepts

  • Chapter 1: Introduction to DNA Structure and Properties

    • Overview of DNA Chemistry (Nucleotides, Phosphodiester Backbone)

    • Double Helix Structure and Conformational Changes

    • DNA Flexibility, Persistence Length, and Polyelectrolyte Nature

    • DNA Hydration and Counterion Condensation

    • Methods for Characterizing DNA (Spectroscopy, Scattering, Microscopy)

  • Chapter 2: Polymers: Structure, Classification, and Solution Properties

    • Types of Polymers (Synthetic, Natural, Polyelectrolytes, Neutral Polymers)

    • Polymer Architecture (Linear, Branched, Block Copolymers)

    • Polymer Conformation in Solution (Random Coil, Globular States)

    • Phase Behavior of Polymer Solutions

    • Responsive Polymers (Thermoresponsive, pH-responsive)

  • Chapter 3: Surfactants: Types, Aggregation, and Phase Behavior

    • Classification of Surfactants (Anionic, Cationic, Nonionic, Zwitterionic)

    • Micelle Formation and Critical Micelle Concentration (CMC)

    • Other Aggregation Structures (Vesicles, Lamellar Phases, Cubosomes)

    • Factors Influencing Surfactant Aggregation

    • Thermodynamics of Micellization

Part II: Interactions Between DNA and Polymers

  • Chapter 4: DNA-Polyelectrolyte Complexes (Polyelectrolyte Condensates)

    • Mechanisms of Polyelectrolyte Complex Formation

    • DNA Condensation by Cationic Polymers (e.g., Polylysine, Polyethylenimine)

    • Effect of Polymer Charge Density, Molecular Weight, and Architecture

    • Structure and Morphology of DNA-Polymer Complexes

    • Thermodynamics and Kinetics of Complexation

  • Chapter 5: Interactions of DNA with Neutral Polymers

    • Crowding Effects and Depletion Forces

    • Phase Separation in DNA-Neutral Polymer Systems

    • Impact on DNA Conformation and Dynamics

    • Specific Binding through Hydrogen Bonding or Hydrophobic Interactions

  • Chapter 6: Stimuli-Responsive DNA-Polymer Systems

    • Temperature-Responsive Polymers for DNA Delivery

    • pH-Responsive Polymers for Intracellular Release

    • Light-Responsive and Redox-Responsive Systems

    • Controlled Assembly and Disassembly of DNA-Polymer Complexes

Part III: Interactions Between DNA and Surfactants

  • Chapter 7: DNA-Cationic Surfactant Interactions

    • Formation of DNA-Cationic Lipid/Surfactant Complexes (Lipoplexes)

    • Structure of Lipoplexes (Lamellar, Hexagonal Phases)

    • Mechanism of DNA Condensation by Cationic Surfactants

    • Factors Affecting Complexation (Charge Ratio, Lipid Composition)

  • Chapter 8: DNA-Anionic and Nonionic Surfactant Interactions

    • Weak Interactions with Anionic Surfactants (e.g., SDS at high concentrations)

    • Limited Interaction with Nonionic Surfactants

    • Effects on DNA Stability and Protein Binding

  • Chapter 9: Reverse Micelles and Microemulsions for DNA

    • Encapsulation of DNA in Reverse Micelles

    • Formation and Stability of DNA-Containing Microemulsions

    • Applications in DNA Extraction and Reactions

Part IV: Applications and Advanced Systems

  • Chapter 10: DNA-Polymer-Surfactant Ternary Systems

    • Complex Coacervation involving DNA, Polyelectrolytes, and Surfactants

    • Hierarchical Assembly in Ternary Systems

    • Tunable Properties for Drug and Gene Delivery

  • Chapter 11: DNA in Gene Delivery and Gene Therapy

    • Non-Viral Gene Delivery Vectors (Polyplexes, Lipoplexes)

    • Challenges in Gene Delivery (Cellular Uptake, Endosomal Escape, Nuclear Entry)

    • Targeted Gene Delivery Strategies

  • Chapter 12: DNA in Nanotechnology and Biosensors

    • DNA as a Building Block for Nanostructures (DNA Origami)

    • Polymer/Surfactant-Assisted DNA Self-Assembly

    • DNA-Based Biosensors and Diagnostic Tools

    • DNA in Drug Encapsulation and Controlled Release

  • Chapter 13: Biomineralization and DNA-Templated Materials

    • Role of DNA in Directed Biomineralization

    • Synthesis of Inorganic Nanomaterials on DNA Templates

    • Hybrid Organic-Inorganic Materials

  • Chapter 14: Future Directions and Challenges

    • Computational Modeling of DNA-Polymer/Surfactant Systems

    • Towards Smart and Responsive DNA-Based Materials

    • Clinical Translation and Industrial Applications

    • Remaining Fundamental Questions

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Tags: Rita S Dias, Bjorn Lindman, DNA, Polymers