Computational methods for understanding riboswitches Volume 553 First Edition by Adamiak, Ryszard Burke, Donald Chen, Shi-Jie ISBN 9780128016183 0128016183
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Computational methods for understanding riboswitches Volume 553 First Edition by Adamiak, Ryszard W. Burke, Donald H. Chen, Shi-Jie- Ebook PDF Instant Download/Delivery: 9780128016183, 0128016183
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Product details:
ISBN 10: 0128016183
ISBN 13: 9780128016183
Author: Adamiak, Ryszard W. Burke, Donald H. Chen, Shi-Jie
“Computational Methods for Understanding Riboswitches” (Volume 553, First Edition, by Adamiak) focuses on the computational and bioinformatics approaches used to study riboswitches — regulatory segments of RNA that bind small molecules to influence gene expression. The volume covers a range of methodologies, including:
Sequence analysis and motif discovery to identify potential riboswitch elements.
Structural modeling and molecular dynamics simulations to understand ligand binding and conformational changes.
Machine learning applications for riboswitch prediction and classification.
Comparative genomics to explore riboswitch conservation across species.
Integration of experimental and computational data for more accurate modeling of riboswitch behavior.
This volume serves as a valuable resource for researchers in RNA biology, bioinformatics, and synthetic biology, offering detailed protocols, algorithms, and case studies to aid in the study of riboswitch function and design.
Table of contents:
1. Introduction
2. Rapid-Scan Method
3. Why Rapid Scan Improves S/N
4. Other Advantages of Rapid Scan
4.1 The Absorption Spectrum Is Obtained Directly
4.2 Passage Effects Are Explicitly Taken into Account
5. Hardware Requirements
5.1 Uniformity of B₁ and Scanned Field over the Sample
5.2 Scan-Coil Driver
5.3 Resonator Design
6. Parameter Selection
6.1 Scan Width
6.2 Linear Versus Sinusoidal Scans
6.3 Resonator Q
6.4 Scan Frequency
7. Examples
7.1 Spin Trapping
7.2 Immobilized Nitroxide
7.3 In Vivo Spectroscopy and Imaging
8. Wider Scans
9. Future Applications
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Tags: Adamiak, Ryszard Burke, Donald Chen, Shi-Jie, Computational methods, understanding riboswitches