Clinical Bioinformatics 2nd Edition by Ronald Trent ISBN 1493908462 978-1493908462

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Product details: 

ISBN 10: 1493908462 

ISBN 13: 978-1493908462

Author:  Ronald Trent

In Clinical Bioinformatics, Second Edition,leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.

Table of contents: 

1 From the Phenotype to the Genotype via Bioinformatics Cali E. Willet and Claire M. Wade
2 Production and Analytic Bioinformatics for Next-Generation DNA Sequencing Richard James Nigel Allcock
3 Analyzing the Metabolome Francis G. Bowling and Mervyn Thomas
4 Statistical Perspectives for Genome-Wide Association Studies (GWAS) Jennifer H. Barrett, John C. Taylor, and Mark M. Iles
5 Bioinformatics Challenges in Genome-Wide Association Studies (GWAS) Rishika De, William S. Bush, and Jason H. Moore
6 Studying Cancer Genomics Through Next-Generation DNA Sequencing and Bioinformatics Maria A. Doyle, Jason Li, Ken Doig, Andrew Fellowes, and Stephen Q. Wong
7 Using Bioinformatics Tools to Study the Role of microRNA in Cancer Fabio Passetti, Natasha Andressa Nogueira Jorge, and Alan Durham
8 Chromosome Microarrays in Diagnostic Testing: Interpreting the Genomic Data Greg B. Peters and Mark D. Pertile
9 Bioinformatics Approach to Understanding Interacting Pathways in Neuropsychiatric Disorders Ali Alawieh, Zahraa Sabra, Amaly Nokkari, Atlal El-Assaad, Stefania Mondello, Fadi Zaraket, Bilal Fadlallah, and Firas H. Kobeissy
10 Pathogen Genome Bioinformatics Vitali Sintchenko and Michael P.V. Roper
11 Setting Up Next-Generation Sequencing in the Medical Laboratory Bing Yu
12 Managing Incidental Findings in Exome Sequencing for Research Marcus J. Hinchcliffe
13 Approaches for Classifying DNA Variants Found by Sanger Sequencing in a Medical Genetics Laboratory Pak Leng Cheong and Melody Caramins

14 Designing Algorithms for Determining Significance of DNA Missense Changes Sivakumar Gowrisankar and Matthew S. Lebo
15 DNA Variant Databases: Current State and Future Directions John-Paul Plazzer and Finlay Macrae
16 Natural Language Processing in Biomedicine: A Unified System Architecture Overview…. Son Doan, Mike Conway, Tu Minh Phuong, and Lucila Ohno-Machado
17 Candidate Gene Discovery and Prioritization in Rare Diseases. Anil G. Jegga
18 Computer-Aided Drug Designing.. Mohini Gore and Neetin S. Desai

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