Chemical Linkers in Antibody Drug Conjugates ADCs 2021 1st Edition by Floris Van Delft, John M Lambert ISBN 1839162635 978-1839162633

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Product details: 

ISBN 10:  1839162635 

ISBN 13: 978-1839162633

Author: Floris Van Delft, John M Lambert 

The covalent conjugation of potent cytotoxic agents to monoclonal antibodies, known as antibody-drug conjugates (ADCs) is a powerful approach in the field of targeted treatment of cancer. Clearly, both monoclonal antibody and cytotoxic payload are crucial elements in determining the clinical value of an ADC and have receive ample attention. However, the structural element connecting the two –the chemical linker– also plays an essential role in mode-of-action, efficacy, pharmacokinetics and safety profile of an ADC, but is often underappreciated in considerations of ADC design.
Chemical Linkers in Antibody–Drug Conjugates aims to shine a detailed light on the various key attributes of chemical linkers in ADCs, for drug-to-antibody ratio, for stability, for release mechanism of payload, for pharmacokinetics, for stability determination, and for efficacy and safety. Ideal for postgraduate students and active researchers in drug discovery and development, this book provides a comprehensive description of linkers used in ADCs (clinical and late preclinical), insight into key quality attributes of linkers for ADCs, and aids the reader in understanding the role of linker chemistry and designing new ADCs.

Table of contents: 

Chapter 1 Introduction to Antibody–Drug Conjugates
Chapter 2 Antibody Conjugation Technologies
Chapter 3 Linker Design and Impact on ADC Properties
Chapter 4 Non-cleavable Linkers: Permanently Linked, for Better or for Worse
Chapter 5 Protease-sensitive Linkers
Chapter 6 Acid-labile Linkers
Chapter 7 ADC Linkers Strategies for the Release of Alcohol-containing Payloads
Chapter 8 Click-cleavable ADC Linkers
Chapter 9 The Use of Uniform PEG Compounds in the Design of ADCs
Chapter 10 Enhancing the Polarity of the Linker-drug in ADCs
Chapter 11 Trastuzumab Deruxtecan Targeting HER2-expressing Cancers with a DXd-ADC System Consisting of a Novel Protease-sensitive Linker and DNA Topoisomerase I Inhibitor with a Hydroxyl Group

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Floris Van Delft,John M Lambert,Chemical Linkers,Antibody Drug