Cardiac Drug Development Guide 1st Edition by Michael Pugsley ISBN 1588290972 978-1588290977

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Product details: 

ISBN 10: 1588290972 

ISBN 13: 978-1588290977

Author: Michael K. Pugsley
Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.

Table of contents: 

Novel Molecular Targets for Cardiac Drug Development
1 The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery – David A. Saint
2 Oxygen Free Radicals in Heart Disease – Elizabeth Roth, Laszlo Hejjel
3 Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology – Tanya Ravingerova, Miroslav Barancik, Monika Strniskova
4 Development of Anti-Inflammatory Drugs for Cardiovascular Disease – Melanie B. Smith, David J. Lefer
5 Development and Use of Platelet Glycoprotein Antagonists in Heart Disease – Joel S. Bennett
6 The Sodium-Hydrogen Exchange System in the Heart – Morris Karmazyn
7 Nitric Oxide and Cardiac Ischemia – Mariarosaria Bucci, Inmaculada Posadas Mayo, Giuseppe Cirino

Functional Endpoints Evaluating Cardiac Drug Activity
8 Ionic Mechanisms of Atrial Fibrillation – J. Christian Hesketh, David Fedida
9 Targeting Ischemic Ventricular Arrhythmias – Michael J. A. Walker, Leon J. Guppy
10 Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease – Hugh Clements-Jewery, Michael J. Curtis
11 Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery – Maurizio Taglialatela
12 Molecular Diversity of Ion Channels in the Mouse Heart – Jeanne M. Nerbonne
13 Delayed Protection of the Myocardium – László Szekeres, James Parratt

Clinical Aspects in Cardiac Drug Development
14 Cardiac Troponin Testing for Detection of Myocardial Infarction

Clinical Aspects in Cardiac Drug Development
15 A Genetic Basis for Cardiac Arrhythmias – Jeffrey A. Towbin, Matteo Vatta, Hua Li, Neil E. Bowles
16 Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy – Hendrik T. Tevaearai, Andrea D. Eckhart, Walter J. Koch
17 The Role of Pharmacometrics in Cardiovascular Drug Development – Paul J. Williams, Amit Desai, Ene Ette
18 Gender Differences in Heart Failure – Mark A. Sussman
19 Angiogenesis Therapies for Coronary Artery Disease

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