Cancer Vaccines Challenges and Opportunities in Translation Translational Medicine 1st Edition by Adrian Bot, Mihail Obrocea ISBN 9780367387556 0367387556
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Product details:
ISBN 10: 0367387556
ISBN 13: 9780367387556
Author: Adrian Bot, Mihail Obrocea
Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: Challenges and Opportunities in Translation is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist.
Cancer Vaccines: Challenges and Opportunities in Translation:
Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential
Discusses “theranostics” as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy
Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer
Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them
Table of contents:
SECTION I – Basic Aspects: Tumor Antigens and Preclinical Modelling
Factoring in Antigen Processing in Designing Anti-Tumor T-Cell Vaccines
Outlining the Gap Between Preclinical Models and Clinical Situation
SECTION II – Cell-Based, Anti-Infectious and Personalized Vaccines
Therapeutic and Prophylactic Cancer Vaccines – Emerging Perspectives from Allogeneic and Infectious Disease Vaccines
Personalized Cancer Vaccines
Dendritic Cell Vaccines for Gliomas
SECTION III – Intracerebral Hemorrhage (ICH)
Peptide-Based Active Immunotherapy in Cancer
Multimodality Immunization Approaches to Improve on DNA Vaccines for Cancer
Bidirectional Bedside–Lab Bench Processes and Flexible Trial Design as a Means to Expedite the Development of Novel Immunotherapeutics
Diagnostic Approaches for Selecting Patient-Customized Therapies, Obviating Tumor Variability to Maximize Therapeutic Effect
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Tags: Adrian Bot, Mihail Obrocea, Cancer Vaccines, Challenges and Opportunities, Translation Translational