Biotechnology and Safety Assessment Third Edition by John Thomas, Roy Fuchs ISBN 0126887217 978-0126887211

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Product details: 

ISBN 10: 0126887217 

ISBN 13: 978-0126887211

Author:  John A. Thomas, Roy L. Fuchs

biotechnology, the authors of Biotechnology and Safety Assessment, 3e, bring readers an up-to-date review of food safety issues, pre-clinical safety and development of new foods and drugs, plant biotechnology, food allergies and safety assessment, and consumer benefits with regard to genetically modified food.

Tomorrow’s foods will be obtained from genetically modified crops, offering consumers higher nutritional value and more of it. Our medications will be obtained through a variety of biotechnological procedures yielding more potent and specific medications for diseases and vaccines. In order to make this view of the future come to light, John A. Thomas and Roy L. Fuchs have updated their classic in order to keep readers one step ahead.

Written by internationally recognized molecular biologists, plant agronomists, microbiologists, toxicologists, nutritionists, and regulatory authorities, this third edition is an excellent and authoritative resource, making it a valuable resource to any biomedical library or scientific bookshelf.

Provides timely coverage on topics of agribiotechnology and biotherapeutics
Describes the recent progress in genetically modified crops and their safety
Presents an update of the newer developments in therapeutic agents
Discusses role of genetically modified microorganisms in the development of new food products
Outlines various global regulatory issues relating to GM crops
Addresses environmental and ecological topics related to GM crops

Table of contents: 

Chapter 1. Using Plant Biotechnology to Reduce Allergens in Food: Status and Future Potential

• Introduction

• Characteristics of Food Allergens

• Traditional Plant Breeding Methods for Reducing Allergenicity

• Use of Genetic Engineering to Reduce Allergenic Potential

• Concluding Remarks

• References

Chapter 2. Experience with Biosafety Research and Postmarket Environmental Monitoring in Risk Management of Crops Derived from Plant Biotechnology

• Introduction

• End Points and Definitions

• Regulatory Aspects

• Biosafety Research on Virus-Resistant Sugar Beet

• Using Biogeographical Data for Biosafety Research

• Monitoring of Insect-Resistant Maize

• Concluding Remarks: Linking Biosafety Research and Monitoring

• References

Chapter 3. Safety Assessment of Foods and Food Ingredients Produced by Genetically Modified Microorganisms

• Introduction

• Issues in Food and Food Ingredients Produced From rDNA

• Concepts in Safety Testing

• Regulatory Requirements

• Case Studies in Safety Assessment

• Concluding Remarks

• References

Chapter 4. Food Safety Assessment of Current and Future Plant Biotechnology Products

• Introduction

• Safety Evaluation and the Substantial Equivalence Paradigm

• How are Genetically Modified Foods Evaluated for Food Safety?

• Future Trends in Food Safety Assessments

• Concluding Remarks and Future Prospects

• References

Chapter 5. Plant Biotechnology Products with Direct Consumer Benefits

• Introduction

• Improved Nutritional Qualities

• Products with Enhanced Quality Traits

• Concluding Remarks

• References

Chapter 6. Animal Feeds from Crops Derived through Biotechnology: Farm Animal Performance and Safety

• Introduction

• Crops Fed to Farm Animals in the United States

• Characteristics of Intake and Digestion by Farm Animals

• Performance, Health, and Nutrient Utilization for Farm Animals Consuming Biotechnology-Derived Crops

• Composition of Meat, Milk, and Eggs from Farm Animals Consuming Biotechnology-Derived Crops

• Detecting Plant Source Proteins and DNA in Animal Products

• Concluding Remarks: Future Directions

• References

Chapter 7. Preclinical Immunotoxicology Assessment of Cytokine Therapeutics

• Introduction

• Cytokines and Their Role in Health and Disease

• Modulation of Cytokine Activity as a Therapeutic Modality

• Clinical Toxicity Associated with Modulation of Cytokine Activity

• Immunotoxicology Assessment of Cytokine Therapeutics

• Concluding Remarks

• References

Chapter 8. Ecological Assessment of Crops Derived through Biotechnology

• Introduction

• Terminology

• Ecological Risk Assessment Principles

• Ecological Risk Assessment Principles for Genetically Modified Plants

• Concluding Remarks

• References

Chapter 9. Ribozyme Technology and Drug Development

• Introduction

• Nonenzymatic Antisense Oligonucleotides as Inhibitors of Specific Gene Expression

• RNA-based Enzymes

• Catalytic DNAs

• Therapeutic Applications of Catalytic Oligonucleotides

• Ribozyme Delivery, Pharmacokinetics, and Metabolism

• Concluding Remarks: Future Prospects

• References

Chapter 10. Biotherapeutics: Current Status and Future Directions

• Introduction

• Recombinant Proteins: Approved for Clinical Use

• Interferon Alfa

• Recombinant Proteins in Clinical Development

• Natural Biological Response Modifiers

• Chemically Defined Biological Response Modifiers

• Combination Chemotherapy, Immunotherapy, and Cellular Therapy

• Concluding Remarks

• References

Chapter 11. Food Allergy Assessment for Products Derived through Plant Biotechnology

• Introduction to Food Allergies and Allergens

• Novel Proteins: Justification for Allergenicity Assessment

• Allergy Assessment in the Gene Discovery Phase

• Decision Tree Approach: The 2001 FAO/WHO Decision Tree

• Example Applications of Allergenicity Assessment

• Concluding Remarks

• References

Chapter 12. Biotechnology: Safety Evaluation of Biotherapeutics and Agribiotechnology Products

• Introduction

• Biotherapeutics

• Agribiotechnology

• Concluding Remarks

• References

Chapter 13. The Potential of Plant Biotechnology for Developing Countries

• Introduction

• Agriculture in Africa

• African Crops and their Problems

• Vaccines for Africa

• Genetically Modified Crops in South Africa

• Genetically Modified Crops in Developing Countries

• The Anti-GMO Lobby and Developing Countries

• Future Directions

• Concluding Remarks

• References

Chapter 14. Preclinical Safety Evaluation of Vaccines

• Introduction

• Regulatory Framework

• Outline of the Proposed Studies

• Concluding Remarks

• References

Chapter 15. Gene Flow from Transgenic Plants

• Introduction

• Initial Hybrid Formation

• Transgene Introgression

• Transgene Spread

• Concluding Remarks

• References

Chapter 16. Safety Assessment of Insect-Protected Cotton

• Introduction

• Molecular Characterization of Bollgard Cotton

• Cry1Ac and NPT II Protein Levels in Bollgard Cotton Plants

• Safety Assessment of the Cry1Ac and NPT II Proteins in Bollgard Cotton

• Compositional Analysis and Nutritional Assessment of Bollgard Cotton

• Horizontal Gene Transfer and the Assessment of Marker Genes

• Environmental Assessment

• Concluding Remarks

• References

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