Biosynthesis of heterocycles from the isolation to gene cluster 1st Edition by Patrizia Diana, Girolamo Cirrincione ISBN 978-1118028674 1118028674

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Product details: 

ISBN 10: 1118028674

ISBN 13:  978-1118028674

Author:  Patrizia Diana, Girolamo Cirrincione

This book describes biosynthetic methods to synthesize heterocyclic compounds, offering a guide for the development of new drugs based on natural products. The authors explain the role of natural products in chemistry and their formation along with important analytical methods and techniques for working with heterocycles.

• Covers methods and techniques: isotopic labelling, enzymes and mutants, and pathway identification
• Provides a thorough resource of information specifically on heterocyclic natural products and their practical biosynthetic relevance
• Explains the role of natural products in chemistry and their formation
• Discusses gene cluster identification and the use of biogenetic engineering in pharmaceutical application

Table of contents: 

1. Cover

2. Contents

3. Preface

4. Acknowledgments

Chapter 1: Introduction
5. 1.1 Natural Products: Primary and Secondary Metabolites
6. 1.2 Common Reactions in Secondary Metabolites
6.1. 1.2.1 Alkylations
6.2. 1.2.2 Wagner-Meerwein Rearrangements
6.3. 1.2.3 Aldol and Claisen Reactions
6.4. 1.2.4 Schiff Base Formation and Mannich Reactions
6.5. 1.2.5 Transaminations
6.6. 1.2.6 Decarboxylations
6.7. 1.2.7 Oxidation and Reduction Reactions
6.8. 1.2.8 Dehalogenation/Halogenation Reactions
6.9. 1.2.9 Glycosylation Reactions
7. References (Chapter 1)

Chapter 2: Techniques for Biosynthesis
8. 2.1 Isotopic Labeling
8.1. 2.1.1 Stable Isotopes
8.2. 2.1.2 Radioactive Isotopes
9. 2.2 Gene Coding for Enzymes
10. 2.3 Combinatorial Biosynthesis
11. References (Chapter 2)

Chapter 3: Three-Membered Heterocyclic Rings and Their Fused Derivatives
12. 3.1 Aziridines and Azirines
12.1. 3.1.1 Azicemicins
12.2. 3.1.2 Miraziridine
12.3. 3.1.3 Maduropeptin
12.4. 3.1.4 Azinomycins
12.5. 3.1.5 Ficellomycin
12.6. 3.1.6 Mitomycins
12.7. 3.1.7 Azirinomycin and Related Azirines
13. 3.2 Oxiranes and Oxirenes
13.1. 3.2.1 Fosfomycin
13.2. 3.2.2 AK, HC, and AF toxins
13.3. 3.2.3 Cerulenin
13.4. 3.2.4 Polyhydroxyalkanoates
13.5. 3.2.5 Epoxyrollins
13.6. 3.2.6 Asperlactone, Aspyrone, Asperline
13.7. 3.2.7 Tajixanthone
13.8. 3.2.8 Cyclomarin
13.9. 3.2.9 Cyclopenin
13.10. 3.2.10 Ovalicin and Fumagillin
13.11. 3.2.11 Methylenomycin A
13.12. 3.2.12 Antibiotic LL-C10037
13.13. 3.2.13 Manumycins
13.14. 3.2.14 Scopolamine
13.15. 3.2.15 Iridoid Glucosides
13.16. 3.2.16 Cordiaquinone
13.17. 3.2.17 Cyclizidine and Indolizomycin
13.18. 3.2.18 Enediyne Antibiotics
13.19. 3.2.19 Macrolides
13.20. 3.2.20 Epothilones
13.21. 3.2.21 Pimaricin
13.22. 3.2.22 Hypothemycin
13.23. 3.2.23 Radicicol and Monocillin I
13.24. 3.2.24 Trichothecenes
13.25. 3.2.25 Sporolides A and B
14. References (Chapter 3)

Chapter 4: Four-Membered Heterocyclic Rings and Their Fused Derivatives
15. 4.1 Azetidine and Azetines
15.1. 4.1.1 Azetidine-2-carboxylic acid
15.2. 4.1.2 Polyoxins
15.3. 4.1.3 Mugineic Acids
15.4. 4.1.4 Tabtoxin and Tabtoxinine-β-lactam
15.5. 4.1.5 Nocardicins
15.6. 4.1.6 Thienamycin
15.7. 4.1.7 Clavulanic Acid and Clavams
15.8. 4.1.8 Penicillins and Cephalosporins
16. 4.2 Oxetanes
16.1. 4.2.1 Oxetanocins
16.2. 4.2.2 Salinosporamides
16.3. 4.2.3 Taxol
17. 4.3 Dithiethanes
17.1. 4.3.1 Tropodithietic acid and Thiotropocin
18. References (Chapter 4)

Chapter 5: Five-Membered Heterocyclic Rings and Their Fused Derivatives
19. 5.1 Pyrroles (Including Tetrapyrroles)
19.1. 5.1.1 2-Acetyl-1-pyrroline
19.2. 5.1.2 Pyrrolnitrin
19.3. 5.1.3 Broussonetines
19.4. 5.1.4 Prodigiosin and Undecylprodigiosin
19.5. 5.1.5 Anatoxin-a and Homoanatoxin-a
19.6. 5.1.6 Nostopeptolides A
19.7. 5.1.7 Pyrrolizidine Alkaloids
19.8. 5.1.8 Toyocamycin and Sangivamycin
19.9. 5.1.9 Tetrapyrroles
20. 5.2 Indoles
20.1. 5.2.1 Indole-3-acetic acid and Glucobrassicin
20.2. 5.2.2 Camalexin
20.3. 5.2.3 Cyclomarazines
20.4. 5.2.4 Rebeccamycin and Staurosporine
20.5. 5.2.5 Paxilline
21. 5.3 Furans
21.1. 5.3.1 Furanomycin
21.2. 5.3.2 Xenofuranones A and B
21.3. 5.3.3 Acyl α-L-Rhamnopyranosides and Rhamnosyllactones
21.4. 5.3.4 Tuscolid and Tuscoron A and B
21.5. 5.3.5 Tetronomycin and Tetronasin
21.6. 5.3.6 Nonactin and Macrotetrolides
21.7. 5.3.7 Furanonaphthoquinone I
22. 5.4 Thiophenes
23. 5.5 Pyrazoles
24. 5.6 Imidazoles
24.1. 5.6.1 Histidine
24.2. 5.6.2 Amaranzole A
24.3. 5.6.3 Oroidin
24.4. 5.6.4 Nikkomycins

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Tags: Patrizia Diana, Girolamo Cirrincione, Biosynthesis of heterocycles, gene cluster