Biopharmaceuticals in Plants Toward the Next Century of Medicine 1st Edition by Kathleen Laura Hefferon ISBN 9781138114951 1138114951
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ISBN 10: 1138114951
ISBN 13: 9781138114951
Author: Kathleen Laura Hefferon
Transgenic plants present enormous potential to become one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary, and agricultural uses. Over the past decade, much progress has been made with respect to the development of vaccines, antibodies, and other therapeutic proteins. Biopharmaceuticals in Plants: Toward the Next Century of Medicine provides a comprehensive survey of all major aspects of the development and production of plant-made biopharmaceuticals.
Accompanied by an exhaustive list of references to facilitate further study, this critical volume:
Describes the theory and practice of modern plant transformation techniques with respect to nuclear and plastic genomes
Outlines the steps involved in the generation of transgenic plants
Discusses the engineering of plant virus expression vectors for transient expression of vaccine proteins and other therapeutics in plant tissue
Addresses the significant role of glycosylation in the production of plant-made mammalian proteins
Investigates the basis of mucosal immunity using plant-based oral vaccines
Examines the scale-up of plant-derived vaccine and therapeutic proteins in entire crops or in large batch cell suspension cultures
Explores the development of clinical trials utilizing plant-derived biopharmaceutical proteins
Evaluates risks and biosafety concerns regarding plant-derived pharmaceuticals
The book concludes with a discussion of the future of plant-based vaccines and other therapeutic proteins with respect to commercial viability and as a tool to improve global public health. Far-reaching in its scope, this text is a baseline reference that students and researchers in a broad range of fields such as medicine, plant science, biotechnology, crop science, natural products chemistry, and engineering will consult regularly. It will also serve as a useful tool for individuals and companies seeking to invest in this dynamic area.
Table of contents:
History of Plants in Production of Biopharmaceuticals
History of Vaccine Development
History of Vaccine Proteins Produced in Plants
Transformation of Plant Tissue
Agrobacterium tumefaciens-Mediated Plant Transformation
Other Transformation Techniques
Problems Associated with Transformation Techniques
Transformation of Cereals
Hairy Root Transformation
Selectable Marker Genes
Regulation of Transgene Expression
Transgenic Plants Expressing Vaccine and Therapeutic Proteins
Transgenic Plants Expressing Vaccines against Diarrheal Diseases
Animal Vaccines Produced in Plants
The Use of Antibodies in Plants as Immunotherapeutic Agents
Other Biopharmaceuticals and Therapeutic Agents Produced in Plants
Enhancement of Plants for Nutritional or Medicinal Purposes (Nutriceuticals)
Chloroplast Engineering and Production of Biopharmaceuticals
Differences between Nuclear and Plastid Transformations
Plastid Transformation
History of Plastid Transformation and Biotechnological Applications
Vaccines and Therapeutic Proteins Produced in Chloroplasts
Plant Viral Expression Vectors and Production of Biopharmaceuticals in Plants
Plant RNA and DNA Virus Expression Systems
Glycosylation of Therapeutic Proteins in Plants
N-Glycosylation
Differences in N-Glycosylation Patterns between Plants and Mammals
Plant-Made Pharmaceuticals and Plant Allergens
Strategies to Humanize Recombinant Proteins in Plants
O-Glycosylation
Sialic Acid in Plants
Glycosylation of Immunoglobulins Produced in Plants
Other Therapeutic Proteins
Scale-Up of Plant-Derived Biopharmaceuticals: Prospects for Commercial Production and for Global Health
Plant-Made Biopharmaceuticals on the Market
Scale-Up and Production of Biopharmaceuticals in Plants
Application of Virus Expression Vectors for Large-Scale Field Trials
Production of Biopharmaceuticals in Plant Suspension Cells
Comparison of Cell Culture over Whole Plants for Biopharmaceutical Production
Other Expression Systems for Large-Scale Production of Biopharmaceuticals
Downstream Processing of Plant-Derived Biopharmaceuticals
Driving Forces behind Plant-Made Biopharmaceuticals: The General Market Environment
The Immune Response to Plant-Derived Pharmaceuticals
The Immune System in General
T Cells
B Cells
Antibodies and the Immune Response
The Concept of Vaccination and Immune Imprinting
Organization of the Mucosal Immune System
Secretory IgA and the Mucosal Epithelium
Mucosal Immune Response of the Respiratory Tract
Oral Tolerance
Preclinical and Clinical Trials Involving Plant-Derived Vaccines
Diarrheal Diseases
Hepatitis B Virus (HBV)
Rabies Virus
Human Papillomavirus (HPV)
Anthrax
Severe Acute Respiratory Syndrome (SARS)
Measles Virus
Influenza Virus
Swine-Transmissible Gastroenteritis Virus
Canine Parvovirus
Oral Tolerance to Antigens
Risk Analysis and Safety of Plant-Made Biopharmaceuticals
Risk Analysis and Plant-Based Biopharmaceuticals
Regulation of Plant-Made Biopharmaceuticals
Quality Control and the Manufacturing of the Product
Impact of Plant-Made Biopharmaceuticals on Human Health
Impact of Plant-Made Biopharmaceuticals on the Environment
Avoiding Transgene Silencing
Epilogue: The Future
The Current State of Plant-Made Biopharmaceuticals
Index
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Tags: Kathleen Laura Hefferon, Biopharmaceuticals in Plants, Next Century