Biointerfaces where material meets biology 1st Edition by Dietmar W Hutmacher, Wojciech Chrzanowski ISBN 1849738767 978-1849738767
Original price was: $50.00.$35.00Current price is: $35.00.
Biointerfaces where material meets biology 1st Edition by Dietmar W Hutmacher, Wojciech Chrzanowski – Ebook PDF Instant Download/Delivery: 1849738767, 978-1849738767
Full download Biointerfaces where material meets biology 1st Edition after payment
Product details:
ISBN 10: 1849738767
ISBN 13: 978-1849738767
Author: Dietmar W Hutmacher, Wojciech Chrzanowski
In order to design and develop new biomaterials it is essential to understand the biointerface, the interconnection between a synthetic or natural material and tissue, microorganism, cell, virus or biomolecule.
Biointerfaces: Where Material Meets Biology provides an up to date overview of the knowledge and methods used to control living organism responses to implantable devices. The book starts with an introduction to the biointerface – past, present and the future perspectives and covers the key areas of biomolecular interface for cell modulation, topographical biointerface, mechano structural biointerafce, chemo-structural biointerfaces and interface that control bacteria responses. By combining the cellular, antimicrobial, antibacterial and therapeutic aspects of the interface with the methodology of fabrication and testing of the synthetic biomaterials used in a variety of medical applications the text provides a handbook for researchers.
Edited by leading researchers, the book integrates the understanding of cell, microorganism and biomolecule interactions with surfaces and the methods used for assessment which will appeal to materials scientists, chemists, biotechnologists, (molecular-) biologists, biomedical engineers interested in the fundamentals and applications of biomaterials and biointerfaces.
Table of contents:
Chapter 1 Protein-based Biointerfaces to Control Stem Cell Differentiation
Jorge Alfredo Uquillas Paredes, Alessandro Polini and Wojciech Chrzanowski
1.1 Modification of Biomaterial Surfaces with Proteins
1.1.1 Introduction
1.1.2 Influence of Modified Surfaces on Cell Adhesion
1.1.3 Influence of Modified Surfaces on Cell Proliferation and Differentiation
1.2 Methods of Protein Immobilization
1.2.1 Surface Functionalization
1.2.2 Determination of Successful Functionalization of Proteins, Growth Factors or Peptides
A Appendix: Protocols for the Visualization and Immobilization of Proteins
A.1 Protocol for the Visualization of Protein on a Surface Using Atomic Force Microscopy
A.2 A Protocol to Determine the Degree of Functionalization of Growth Factors and Small Peptides in Naturally Derived Type I Collagen Hydrogels
A.3 A Protocol to Immobilize Growth Factors and Small Peptides by ‘Classic’ Physisorption
A.4 A Protocol to Immobilize Growth Factors and Small Peptides by Polydopamine Coating-based Physisorption
A.5 Protocol to Immobilize Growth Factors and Small Peptides by Silanization-based Physisorption
References
Chapter 2 Additive Manufacturing and Surface Modification of Biomaterials using Self-assembled Monolayers
Jayasheelan Vaithilingam, Ruth D. Goodridge, Steven D. R. Christie, Steve Edmondson and Richard J. M. Hague
2.1 Introduction
2.1.1 Issues with Current Biomedical Implants
2.1.2 Scope of this Chapter
2.2 Additive Manufacturing
2.2.1 Selective Laser Melting
2.3 Surface Modification
2.3.1 Issues with Current Surface Modification Techniques
2.3.2 Surface Modification Using Self-assembled Monolayers
2.3.3 Functionalisation of Self-assembled Monolayers
2.4 Case Study
2.4.1 Functionalisation of Selective Laser Melted Parts with Ciprofloxacin using Self-assembled Monolayers
2.4.2 Surface Functionalisation using Ciprofloxacin
2.5 Conclusion
References
Chapter 3 Probing Biointerfaces: Electrokinetics
Ralf Zimmermann, Jérôme F. L. Duval and Carsten Werner
3.1 Introduction
3.2 Fundamental Principles and Theory
3.2.1 Streaming Current and Streaming Potential Measurements in Rectangular Microchannels
3.2.2 Surface Conductivity
Fluidity Modulation in Phospholipid Bilayers by Electrolyte Ions
3.4 Summary
A Appendix: Methods
A.1 Measurement of Streaming Current/Potential
A.2 Simulations of the Electro-Hydrodynamics at Diffuse Soft Interfaces
A.3 Thin Polymer Films for Streaming Current/Potential Measurements
References
Chapter 4 Growth Factor Delivery Systems for the Treatment of Cardiovascular Diseases
Natalia Zapata, Elisa Garbayo, Maria J. Blanco-Prieto and Felipe Prosper
4.1 Introduction
4.2 Drug Delivery Systems for Growth Factors
4.2.1 Growth Factors
4.2.2 Biomaterials
4.3 Growth Factor Drug Delivery Systems for Cardiac Applications
4.3.1 Angiogenesis
4.3.2 Direct Effect on Cardiac Cell Proliferation, Remodeling, Tissue Protection and Differentiation
4.3.3 Other Proteins
4.3.4 Combined Therapies
4.4 Growth Factor Delivery Systems and Cell Therapy
4.5 Conclusions
Acknowledgements
References
Section B Structural Biointerfaces
Chapter 5 Titanium Phosphate Glass Microspheres as Microcarriers for In Vitro Bone Cell Tissue Engineering
Nilay J. Lakhkar, Carlotta Peticone, David DeSilva-Thompson, Ivan B. Wall, Vehid Salih and Jonathan C. Knowles
5.1 Introduction
5.2 Production of Titanium Phosphate Glass Microspheres by Flame Spheroidisation
5.2.1 Materials
5.2.2 Equipment
5.2.3 Calculations of the Precursor Amounts
5.2.4 Preparation of Glass Microparticles
5.2.5 Design of Flame Spheroidisation Apparatus
5.2.6 Preparation of Glass Microspheres
5.2.7 Expected Outcomes and Other Considerations
5.3 Visualisation and Quantification of Microsphere Degradation by Time-lapse Imaging
5.3.1 Materials
5.3.2 Equipment
5.3.3 Setting Up a Time-lapse Experiment
5.3.4 Expected Outcomes and Other Considerations
5.4 Cell Culture of Microspheres with Bone Cells
5.4.1 Materials and Reagents
5.4.2 Equipment
5.4.3 Seeding of MG63 Cells on Microspheres
5.4.4 Sample Preparation for Scanning Electron Microscopy
5.4.5 Expected Outcomes and Other Considerations
5.5 Summary: On-going Work and Future Directions
References
Chapter 6 Biointerfaces Between Cells and Substrates in Three Dimensions
Adam S. Hayward, Neil R. Cameron and Stefan A. Przyborski
6.1 The Structural and Physiological Relevance of Three-dimensional Biointerfaces
6.2 Using Natural and Synthetic Materials to Create Three-dimensional Biointerfaces
6.2.1 Sandwiching Cells with Extracellular Matrix Proteins
6.2.2 Hydrogels
6.2.3 Electrospun Polymer Fibres
6.2.4 Three-dimensional Printed Scaffolds
6.2.5 Porous Polymeric Scaffolds
6.2.6 Emulsion Templating and Alvetex
6.3 Methods to Examine Cell Behaviour in Three Dimensions: Alvetex Case Study
6.3.1 Imaging of Live Cells
6.3.2 Histology and Immunocytochemistry
6.3.3 Electron Microscopy
6.3.4 Metabolic Assays and Other Functional Experiments
6.3.5 Genomics and Proteomics
6.3.6 Cell Retrieval
6.4 Future Direction of Biointerfaces in Three Dimensions
References
Section C Multi-functional Biointerfaces
Chapter 7 Interfaces in Composite Materials
Ensanya A. Abou Neel, Wojciech Chrzanowski and Anne M. Young
7.1 Introduction
7.1.1 Biomedical Applications of Composites
7.2 Composite Interfaces
7.2.1 Filler–Matrix
7.2.2 Composite-surrounding Environment
7.3 State-of-the-Art ‘Talking’ to Living Organisms
7.3.1 Smart Composites Based on Biomimetic Matrices
7.3.2 On-demand Responsive Composites
7.3.3 Composites Based on Smart Fillers
7.3.4 Functionalized Composites
7.4 Interfaces of Clinical Importance
7.4.1 The Osteochondral Interface
7.4.2 Neuromuscular Prosthesis–Tissue Interface
7.4.3 Composite–Dentin Interface
7.5 Step-by-Step Preparation of an Example of Smart Composites
7.5.1 Synthesis of Poly(lactide-co-propyleneglycol-co-lactide) co-oligomer
7.5.2 Methacrylation of Poly(lactide-co-propyleneglycol-co-lactide) co-oligomer
7.5.3 Preparation of the Composite
7.6 Advances and Challenges
References
Chapter 8 Bioactive Conducting Polymers for Optimising the Neural Interface
Josef Goding, Rylie Green, Penny Martens and Laura Poole-Warren
8.1 Introduction
8.2 Conducting Polymers
8.2.1 Mechanism of Conduction
8.2.2 Fabrication
8.2.3 Characterisation
8.2.4 Biomedical Applications of Conducting Polymers
8.2.5 Limitations of Conducting Polymers in Neural Interfaces
8.3 Biofunctionalisation of Conducting Polymers
8.3.1 Incorporation of Bioactive Molecules
8.3.2 Conducting Polymers as Bioactive Surfaces
8.3.3 Conducting Polymers as Drug Delivery Devices
8.3.4 Limitations of Biofunctionalised Conducting Polymers
8.4 Modified Biofunctional Conducting Polymers for Neural Interfaces
8.4.1 Structured Conducting Polymers
8.4.2 Conducting Polymer Composites
8.5 Conclusion
A Appendix: Methodologies and Practical Advice
A.1 Fabrication: Electrochemical Deposition
A.2 Characterisation
References
Chapter 9 Polycaprolactone-based Scaffolds Fabricated Using Fused Deposition Modelling or Melt Extrusion Techniques for Bone Tissue Engineering
Patrina S. P. Poh, Michal Bartnikowski, Travis J. Klein, Giles T. S. Kirby và Maria A. Woodruff
9.1 Introduction
9.1.1 Bone Tissue Engineering
9.1.2 Polymers Used in Bone Tissue Engineering
9.2 Scaffold Fabrication Techniques
9.2.1 Principles of Additive Manufacturing: Fused Deposition Modelling and Melt Extrusion
9.3 Polycaprolactone Scaffolds
9.3.1 Physical Characteristics of Polycaprolactone Scaffolds
9.3.2 Polycaprolactone Scaffold In Vitro Analysis
9.4 Polycaprolactone-based Composite Scaffolds
9.4.1 Polycaprolactone with Hydroxyapatite
9.4.2 Polycaprolactone with Tricalcium Phosphate
9.5 Surface Functionalisation of Polycaprolactone-based Scaffolds
9.5.1 Polycaprolactone with Bone Marrow Aspirate
9.5.2 Polycaprolactone with Heparin
9.5.3 Collagen-mimetic Peptide: The Peptide Sequence GFOGER
9.5.4 Plasma Modification and Fibronectin Coating
9.5.5 Hydroxyl Functionalisation
9.5.6 Carbonated Hydroxyapatite–Gelatin Composite
9.5.7 Phlorotannin Conjugations
9.6 Polycaprolactone-based Scaffolds as Drug Carriers
9.6.1 Antibiotics
9.6.2 Adeno-associated Virus Encoding Bone Morphogenetic Protein-2
9.6.3 Bone Morphogenetic Protein
9.7 Advanced Scaffold Architecture
9.7.1 Scaffolds with Vascular Channels
9.7.2 Hybrid Osteochondral Scaffolds
9.8 Clinical Studies
9.9 Conclusions
A Appendix: Methods Section
A.1 Mixing Polycaprolactone with Bioactive Glass Particles by Fast Precipitation into Excess 100% Ethanol
A.2 Mathematical Derivation of Melt Extruded Scaffold Microfilament Diameter from Translational Velocity
Acknowledgements
References
—
Section D Chemo-structural Biointerfaces
Chapter 10 High Throughput Techniques for the Investigation of Cell–Material Interactions
Lauren R. Clements, Helmut Thissen và Nicolas H. Voelcker
10.1 Introduction
10.1.1 Influence of Material Surface Chemistry and Topography on Cell Behaviour
10.1.2 Stem Cell–Material Surface Interactions
10.1.3 Screening of Cell–Surface Interactions: An Overview of High-throughput Techniques
10.2 Gradient Surfaces
10.2.1 Topography Gradients
10.2 Gradient Surfaces
10.2.2 Chemical Gradients
10.2.3 Biological Density Gradients
10.2.4 Two-dimensional Chemical Gradients
10.2.5 Topography: The Chemistry of Two-dimensional Gradients
10.2.6 Two-dimensional Topography Gradients
10.3 Conclusions
References
—
Chapter 11 Grafting of Functional Monomers on Biomaterials
Lisbeth Grøndahl và Jing Zhong Luk
11.1 Introduction
11.2 Methods for Grafting of Functional Monomers
11.2.1 Simultaneous Grafting
11.2.2 Peroxy/hydroxyl Grafting
11.2.3 Controlled Radical Polymerisation Grafting from a Surface
11.2.4 Plasma Polymerisation
11.2.5 Grafting of Functional Monomers to Porous Substrates
11.3 Characterisation of Grafted Materials
11.3.1 Chemical Characterisation of Surfaces
11.3.2 Physical Characterisation of Surfaces
11.3.3 Characterisation of Grafted Chains
11.3.4 Lateral Distribution of Grafted Chains
11.3.5 Penetration Depth of Grafted Chains
11.4 Concluding Remarks
Acknowledgements
References
—
Chapter 12 Design of Mobile Supramolecular Biointerfaces for Regulation of Biological Responses
Ji-Hun Seo và Nobuhiko Yui
12.1 Introduction
12.2 Hydrated Viscoelastic Factor of Polymeric Biomaterials
12.3 Designing Dynamic Surface for Regulation of Hydrated Viscoelastic Factor
12.4 Biological Responses on the Dynamic Surfaces
12.4.1 The Effect of Hydrated Viscoelastic Properties on Fibrinogen Adsorption
12.4.2 Platelet Responses on the Dynamic Surfaces
13.6 Summary
References
—
Chapter 14 Antibacterial Coatings for Biomedical Implants
Alexandra M. R. De Volder và Annelies M. C. R. Zwaag
14.1 Introduction
14.2 Antibacterial Coating Strategies
14.2.1 Release-based Antibacterial Coatings
14.2.2 Contact-killing Antibacterial Coatings
14.2.3 Anti-fouling Coatings
14.3 Characterisation of Antibacterial Coatings
14.3.1 Surface Characterisation
14.3.2 Bacterial Viability Assays
14.3.3 In Vivo Testing
14.4 Future Trends and Challenges
Acknowledgements
References
—
Chapter 15 Nanostructured Surfaces to Control Bacterial Response
Elena Ivanova và Russell J. Crawford
15.1 Introduction
15.2 Mechanisms of Bacterial Inhibition by Nanostructured Surfaces
15.2.1 Physical Disruption of Bacterial Cell Walls
15.2.2 Interference with Bacterial Metabolism
15.3 Fabrication Methods for Nanostructured Surfaces
15.3.1 Lithography Techniques
15.3.2 Plasma Etching
15.3.3 Self-assembly Techniques
15.4 Applications in Biomedical Devices
15.5 Conclusions
References
Chapter 15 Smart Antimicrobial Coatings for Medical Devices
Lisa A. Cramer và Richard W. Potter
15.1 Introduction
15.2 Mechanisms of Antimicrobial Coatings
Release-based coatings
Contact-active coatings
Anti-fouling coatings
15.3 Material Design and Fabrication Techniques
15.4 Characterisation Methods
15.5 Applications in Medical Devices
15.6 Future Prospects and Challenges
References
Appendix B: Supplementary Data
B.1 Data from Surface Modification Experiments
B.2 Statistical Analysis of Bacterial Adhesion Tests
B.3 AFM Imaging Data
People also search for:
biointerfaces where material meets biology
biointerface lab
biointerfaces 2022
interfaces biological materials
biointerface journal
Tags:
Dietmar W Hutmacher,Wojciech Chrzanowski,Biointerfaces where,meets biology