Bioactive Heterocyclic Compound Classes Pharmaceuticals 1st Edition by Clemens Lamberth, Jürgen Dinges ISBN 978-3527664467 3527664467

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Product details: 

ISBN 10:   3527664467

ISBN 13: 978-3527664467

Author:  Clemens Lamberth, Jürgen Dinges 

The chemistry of heterocycles is an important branch of organic chemistry. This is due to the fact that a large number of natural products, e. g.
hormones, antibiotics, vitamins, etc. are composed of heterocyclic structures. Often, these compounds show beneficial properties and are therefore applied as pharmaceuticals to treat diseases or as insecticides, herbicides or fungicides in crop protection.
This volume presents important pharmaceuticals. Each of the 20 chapters covers in a concise manner one class of heterocycles, clearly structuredas follows:

* Structural formulas of most important examples (market products)
* Short background of history or discovery
* Typical syntheses of important examples
* Mode of action
* Characteristic biological activity
* Structure-activity relationship
* Additional chemistry information (e.g. further transformations, alternative syntheses, metabolic pathways, etc.)
* References.

A valuable one-stop reference source for researchers in academia and industry as well as for graduate students with career aspirations in the
pharmaceutical chemistry.

Table of contents: 

1. Tropane-Based Alkaloids as Muscarinic Antagonists
Royer J., Editor

2. Morphinone-Based Opioid Receptor Agonist Analgesics
3. Barbituric Acid-Based GABAA Receptor Modulators
4. Phenothiazine-Based Dopamine D2 Antagonists for Treatment
5. Arylpiperazine-Based 5HT1A Receptor Partial Agonists and 5HT2A
6. Arylpiperidine-Based Dopamine D2 Antagonists and 5HT2A
7. Dibenzazepine-Based Sodium Channel Blockers for Treatment
8. Guanine-Based Nucleoside Analogs as Antiviral Agents
Fattorusso E, Taglialatela-Scafati

9. Penicillin and Cephalosporin Antibiotics
10. Pyrimidine-Based Kinase Inhibitors in Cancer Chemotherapy
11. Modern Alkaloids
12. Benzyl Triazole-Based Aromatase Inhibitors for Treatment
13. Dihydropyridine-Based Calcium Channel Blockers
14. Asymmetric Synthesis
15. Thiazide-Based Diuretics for the Treatment of Hypertension
16. Adenine-Based Reverse Transcriptase Inhibitors as Anti-HIV Agents
17. Tetrahydropyranone-Based HMG-CoA Reductase Inhibitors
18. Benzimidazole-Based H⁺K⁺ATPase Inhibitors for Treatment

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