Big on Bk Current Insights into the Function of Large Conductance Voltage and Ca Activated K Channels at the Molecular Cellular and Systemic Levels 1st Edition by Candice Contet ISBN 978-0128036198 0128036192

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Product details: 

ISBN 10: 0128036192

ISBN 13:  978-0128036198

Author: Candice Contet

Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into this area. It reviews current knowledge and understanding, and also provides a starting point for researchers and practitioners entering the field.

The latest volume in the International Review of Neurobiology series
Provides a broad coverage of subject matter at the molecular, cellular and systemic levels
Presents an ideal resource for researchers and practitioners, and those just entering the field

Table of contents: 

1. Introduction

2. Voltage-Dependent Gating in BK Channels

2.1 Our Current Understanding of Voltage-Dependent Channel Gating

2.2 Operation of the Noncanonical BK Channel VSD

2.3 Modulation of BK Voltage-Dependent Gating

3. Ligand-Dependent Gating in BK Channels

3.1 Ca²+-Dependent Gating

3.2 Mg2+-Dependent Gating

4. The BK Allosteric Gating Mechanism

4.1 The HCA and HA Models of Allosteric BK Channel Activation

4.2 Electromechanical Coupling

4.3 Modulation of Electromechanical Coupling

4.4 Coupling Between the Ca²+ Sensors and the Gate

4.5 Modulation of BK Ca2+ Sensitivity

4.6 Coupling Between Voltage and Ca²+ Sensors

4.7 Coupling Between RCK1 and RCK2 Ca²+ Sensors

5. The Extraordinary Conductance of BK Channels

6. Concluding Remarks: The BK Channel as a Rebel and a Model

Acknowledgments

References

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Tags: Candice Contet, Big on Bk, the Function, Large Conductance