An introduction to toxicogenomics 1st Edition by Michael Burczynski ISBN 978-0849313349 0849313341

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Product details: 

ISBN 10:  0849313341

ISBN 13: 978-0849313349

Author:  Michael E. Burczynski

Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Table of contents: 

I. FUNDAMENTALS OF EXPRESSION PROFILING ANALYSIS

1. Preparation and Utilization of Microarrays
    Sophie Wildsmith and Fiona Spence

2. Comparative Studies Using cDNA versus Oligonucleotide Arrays
    Jiang Li and Jeffrey A. Johnson

3. Quality Control of Expression Profiling Data
    Andrew Hill and Maryann Whitley

4. An Introduction to Cluster Analysis
    Frederick Immermann and Youping Huang

II. EXPRESSION PROFILING AND TOXICOLOGY: THE ADVENT OF TOXICOGENOMICS

5. Transcriptional Profiling in Toxicology
    Julia Scheel, Marie-Charlotte von Brevern, and Thorsten Storck

III. MODEL SYSTEMS IN TOXICOGENOMIC STUDIES

6. Microarrays in Drug Metabolism and Toxicology: Rat Liver Responses to Prototypical CYP Inducers
    David Gerhold, Jian Xu, and Thomas Rushmore

7. Characterization of Hepatocytes and Their Use as a Model System in Toxicogenomics
    Thomas K. Baker, Marnie A. Higgins, Mark A. Carfagna, and Timothy P. Ryan

IV. MECHANISTIC TOXICOGENOMICS

8. Molecular Signatures of Dioxin Toxicity
    J. Kevin Kerzee, Craig R. Tomlinson, Jennifer L. Marlowe, and Alvaro Puga

9. Toxicogenomic Dissection of the Antioxidant Response
    Jiang Li and Jeffrey A. Johnson

10. An Overview of Mechanistic Toxicogenomic Studies
     Julia Scheel, Marie-Charlotte von Brevern, and Thorsten Storck

V. PREDICTIVE TOXICOGENOMICS

11. Gene Expression Profile Databases in Toxicity Testing
     Robert T. Dunn II and Kyle L. Kolaja

12. Predictive Toxicogenomics
     Mark W. Porter, Arthur L. Castle, Michael S. Orr, and Donna L. Mendrick

13. Unsupervised Hierarchical Clustering of Toxicants
     Jeffrey F. Waring and Roger G. Ulrich

14. Toxicogenomic Analysis in Clinical Pharmacogenomic Studies
     Michael E. Burczynski

VI. THE FUTURE OF TOXICOGENOMICS

15. The Future of Toxicogenomics
     John C. Rockett

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