Adaptive Design Methods in Clinical Trials Second Edition by Shein-Chung Chow, Mark Chang ISBN 978-1439839874 1439839875

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Product details: 

ISBN 10:  1439839875

ISBN 13: 978-1439839874

Author: Shein-Chung Chow, Mark Chang

With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA’s recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology.

New to the Second EditionAlong with revisions throughout the text, this edition significantly updates the chapters on protocol amendment and clinical trial simulation to incorporate the latest changes. It also includes five entirely new chapters on two-stage adaptive design, biomarker adaptive trials, target clinical trials, sample size and power estimation, and regulatory perspectives.

Following in the tradition of its acclaimed predecessor, this second edition continues to offer an up-to-date resource for clinical scientists and researchers in academia, regulatory agencies, and the pharmaceutical industry. Written in an intuitive style at a basic mathematical and statistical level, the book maintains its practical approach with an emphasis on concepts via numerous examples and illustrations.

Table of contents: 

1. Introduction

2. Protocol Amendment

3. Adaptive Randomization

4. Adaptive Hypotheses

5. Adaptive Dose-Escalation Trials

6. Adaptive Group Sequential Design

7. Statistical Tests for Seamless Adaptive Designs

8. Adaptive Sample Size Adjustment

9. Two-Stage Adaptive Design

10. Adaptive Treatment Switching

11. Bayesian Approach

12. Biomarker Adaptive Trials

13. Target Clinical Trials

14. Sample Size and Power Estimation

15. Clinical Trial Simulation

16. Regulatory Perspectives — A Review of FDA Draft Guidance

17. Case Studies

18. Bibliography

19. Subject Index

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