About Thalassaemia 1st Edition by Androulla Efeftheriou ISBN 9789963623402 9963623409
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Product details:
ISBN 10: 9963623409
ISBN 13: 9789963623402
Author: Dr. Androulla Efeftheriou
Table of contents:
Chapter 1
Blood and Thalassaemia
Blood “the river offer The role of blood Composition of blood Whole blood Blood types/groups Diseases of the blood Thalassaemia major
Chapter 2
Genetics and Thalassaemia
Genes
The defect in red blood cells
that leads to Thalassemia major
Haemoglobin and iton Genes controlling globin synthesis The pathophysiology of thalassaemia Lack of B-chains and exces of a-chains Diagnosing Thalassaemia Haematological methods commonly used to diagnose Thalassaemia major The treatment of B-thalassemia major
Chapter 3
Blood transfusion therapy
When to begin transfusion therapy Ensuring safe transfusion therapy Blood group genotype What to transfuse Drawing up a transfusion regime Assessing the effectiveness of a blood transfusion regime Treating transfusion reactions
Chapter 4
Iron Overload and iron Chelation
on in a healthy body on in Thalassaemia
How excess on damages the body Desfenicxamine DFO or Desferal
When to start on chelation treatment Other ways of administering DFO Evaluating the effectiveness of DFO treatment Using ferritin levels to adjust doses of DFO
on content in the wine Complications associated with DFO and how these may be addressed
Pregnancy
Compliance with desexamine therapy
Other drugs for removing iton
How deferiprone D works
Efficiency of deferiprone
Adverse Effects of L1
Other side effects of deferiprone
Using Deferiprone in combination with DFO
New ord dug for removd of excess iron Deferasirox
Chapter 5
Medical problems associated with thalassaemia and its treatment
Hypersplenism
Splenectomy and infections
Heart and endocrine complications
Heart complications
Endocrine complications
Chapter 6
Infections in thalassaemia
Transfusion-associated infections
Hepatitis B virus (HBV) infection
Hepatitis C HCV)
Other viruses
New pathogens
New womes from old pathogens
Blood safety
Safety and availability of blood in the developing world
Summary of what eventually happens
Chapter 7
in untreated thalassaemia major
Thalassaemia intermedia and other thalassaemias
Diagnosis
Management of thalassaemia intermedia
lon chelation
Medical problems in Thalassaemia intermedia
Thalassaemias associated with “abnormal haemoglobin or structural haemoglobin variants
Compound abnormal haemoglobins with-thalassaemia
Chapter 8
Therapeutic regimes established and future approaches
Bone marrow transplantation (BMT)
what is a bone marrow
transplant?
What are the risks?
How can the risks be minimised?
Other approaches to bone marrow transplantation
with an exact match belated
Cord blood transplantation
Conclusion
Chapter 9
Other approaches to treatment
Fortal haemoglobin inducers
Gene Therapy
Pre-implantation diagnosis with HLA-matching
Chapter 10
Psychosocial issues
The patient
The parent
Patients and parents
Getting information and support
The infant child, the adolescent and the adult patient with thalassemia major
Chapter 11
Some additional information
Survival and quality of life
Chapter 12
Epidemiology and prevention of thalassaemia
Epidemiology
Prevention
The importance of prevention
How Thalassaemia is inherited
Aboutcomers of the Thalassemia
Why important to know if you are a carier Other abnormal haemoglobins
and haemoglobin disorders
a-thalassaemia
Finding out whether you are a commer
who should have a blood test
Consanguinity
The choices available for an at-risk couple
Testing a foetus for thalassaemia
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