Nucleic acids in chemistry and biology 3rd Edition by Michael Blackburn, Michael Gait, David Loakes, David Williams ISBN 978-0854046546 0854046542

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Product details: 

ISBN 10:  0854046542

ISBN 13: 978-0854046546

Author: G. Michael Blackburn, Michael J. Gait, David Loakes, David Williams

The 3rd edition of Nucleic Acid in Chemistry and Biology has been extensively updated from previous releases. Featuring an expanded group of editors and contributors, this leading textbook offers a thorough and up-to-date background in all modern aspects of Nucleic Acid Chemistry and Biology. Coverage includes both the chemistry and biology of nucleic acids; the chemical synthesis of nucleosides and nucleotides; and, the chemistry for the synthesis of oligonucleotides and analogues.

Table of contents: 

• Introduction and Overview

  • 1.1: The Biological Importance of DNA

  • 1.2: The Origins of Nucleic Acids Research

  • 1.3: Early Structural Studies on Nucleic Acids

  • 1.4: The Discovery of the Structure of DNA

  • 1.5: The Advent of Molecular Biology

  • 1.6: The Partnership of Chemistry and Biology

  • 1.7: Frontiers in Nucleic Acids Research

• DNA and RNA Structure

  • 2.1: Structures of Components

  • 2.2: Standard DNA Structures

  • 2.3: Real DNA Structures

  • 2.4: Structures of RNA Species

  • 2.5: Dynamics of Nucleic Acid Structures

  • 2.6: Higher-order DNA Structures

• Nucleosides and Nucleotides

  • 3.1: Chemical Synthesis of Nucleosides

  • 3.2: Chemistry of Esters and Anhydrides of Phosphorus Oxyacids

  • 3.3: Nucleoside Esters of Polyphosphates

  • 3.4: Biosynthesis of Nucleotides

  • 3.5: Catabolism of Nucleotides

  • 3.6: Polymerisation of Nucleotides

  • 3.7: Therapeutic Applications of Nucleoside Analogues

• Synthesis of Oligonucleotides

  • 4.1: Synthesis of Oligodeoxyribonucleotides

  • 4.2: Synthesis of Oligoribonucleotides

  • 4.3: Enzymatic Synthesis of Oligonucleotides

  • 4.4: Synthesis of Modified Oligonucleotides

• Nucleic Acids in Biotechnology

  • 5.1: DNA Sequence Determination

  • 5.2: Gene Cloning

  • 5.3: Enzymes Useful in Gene Manipulation

  • 5.4: Gene Synthesis

  • 5.5: The Detection of Nucleic Acids Sequences by Hybridization

  • 5.6: Gene Mutagenesis

  • 5.7: Oligonucleotides as Reagents and Therapeutics

  • 5.8: Footprinting

• Genes and Genomes

  • 6.1: Gene Structure

  • 6.2: Gene Families

  • 6.3: Intergenic DNA

  • 6.4: Chromosomes

  • 6.5: DNA Sequence and Bioinformatics

  • 6.6: Copying DNA

  • 6.7: DNA Mutation and Genome Repair

  • 6.8: DNA Recombination

• RNA Structure and Function

  • 7.1: Overview of RNA Structural Motifs

  • 7.2: RNA Processing and Modification

  • 7.3: RNAs in the Protein Factory: Translation

  • 7.4: RNAs Involved in Export and Transport

  • 7.5: RNAs and Epigenetic Phenomena

  • 7.6: RNA Structure and Function in Viral Systems

• Covalent Interactions of Nucleic Acids with Small Molecules and Their Repair

  • 8.1: Hydrolysis of Nucleosides, Nucleotides, and Nucleic Acids

  • 8.2: Reduction of Nucleosides

  • 8.3: Oxidation of Nucleosides, Nucleotides, and Nucleic Acids

  • 8.4: Reactions with Nucleophiles

  • 8.5: Reactions with Electrophiles

  • 8.6: Reactions with Metabolically Activated Carcinogens

  • 8.7: Reactions with Anti-cancer Drugs

  • 8.8: Photochemical Modification of Nucleic Acids

  • 8.9: Effects of Ionising Radiation on Nucleic Acids

  • 8.10: Biological Consequences of DNA Alkylation

  • 8.11: DNA Repair

• Reversible Small Molecule–Nucleic Acid Interactions

  • 9.1: Introduction

  • 9.2: Binding Modes and Sites of Interaction

  • 9.3: Counter-ion Condensation and Polyelectrolyte Theory

  • 9.4: Non-specific Outside-edge Interactions

  • 9.5: Hydration Effects and Water-DNA Interactions

  • 9.6: DNA Intercalation

  • 9.7: Interactions in the Minor Groove

  • 9.8: Intercalation versus Minor Groove Binding

  • 9.9: Co-operativity in Ligand-DNA Interactions

  • 9.10: Small Molecule Interactions with Higher-order DNA

• Protein–Nucleic Acid Interactions

  • 10.1: Structural Features of DNA Important in Protein Recognition

  • 10.2: The Physical Chemistry of Protein-Nucleic Acid Interactions

  • 10.3: Representative DNA Recognition Motifs

  • 10.4: Kinetic and Thermodynamic Aspects of Protein-Nucleic Acid Interactions

  • 10.5: The Specificity of DNA Enzymes

  • 10.6: DNA Packaging

  • 10.7: Polymerases

  • 10.8: Machines that Manipulate Duplex DNA

  • 10.9: RNA-Protein Interactions and RNA-mediated Assemblies

• Physical and Structural Techniques Applied to Nucleic Acids

  • 11.1: Spectroscopic Techniques

  • 11.2: Nuclear Magnetic Resonance

  • 11.3: X-ray Crystallography

  • 11.4: Hydrodynamic and Separation Methods

  • 11.5: Microscopy

  • 11.6: Mass Spectrometry

  • 11.7: Molecular Modelling and Dynamics

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Tags: Michael Blackburn, Michael Gait, David Loakes, David Williams, Nucleic acids, chemistry and biology