Insulin Resistance and Insulin Resistance Syndrome Frontiers in Animal Diabetes Research 5 1st Edition by Eleazar Shafrir, Barbara Hansen ISBN 978-0415291972 0415291976

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ISBN 10:  0415291976

ISBN 13:  978-0415291972

Author: Eleazar Shafrir, Barbara Hansen

Type II diabetes has developed into a global epidemic, with nearly 20 type II patients for every type I individual. Preceding the onset of type II diabetes is a prolonged episode of insulin resistance featuring a host of detrimental symptoms. This period comprises a disease referred to as Insulin Resistance Syndrome or Metabolic Syndrome.

Insulin Resistance and Insulin Resistance Syndrome deals with the cellular and whole body pathogenic mechanisms and phenotypic expressions in various models of insulin resistance. Leaders in the field provide their perspectives on the mechanisms of insulin resistance, as observed in various animal models. While the exact mechanism underlying resistance to insulin is unknown, the authors review many of the significant factors. A series of chapters on Metabolic Syndrome discusses its possible insulin resistance-associated pathophysiology with obesity, cardiovascular disease, hypertension, glucose intolerance, and abnormalities in whole body metabolism.

Presenting essential knowledge in the field of insulin resistance, this book will benefit clinicians, pharmaceutical scientists, and researchers involved in endocrinology, biochemistry and metabolism in diabetes.

Table of contents: 

1 Metabolism and Hypertension
1 Insulin Resistance and Glycogen Synthesis: Roles in Liver, Muscle and Adipose Tissue – Hagit Eldar-Finkelman and Merav Yarkoni
2 Gestational Diabetes and Maternal Insulin Resistance in the C57BLKS/JLepra/+ Mouse – Jianhua Shao and Jacob E. Friedman
3 Role of Protein-Tyrosine Phosphatases in Insulin Action and Insulin Resistance – Barry J. Goldstein
4 Hypertension and Insulin Resistance in the Wistar Fatty Rat – Masami Suzuki, Hiroyuki Odaka and Yasuo Sugiyama
5 Cardiovascular Disease in the Insulin-Resistant, Atherosclerosis-Prone JCR: LA-cp Rat – J.C. Russell and S.E. Kelly
6 The C57BL/6J Mouse as a Model of Insulin Resistance and Hypertension – Tonya Martin, Sheila Collins and Richard S. Surwit

2 Molecular and Genetic
7 Molecular Features of Insulin Resistance, Obesity and Type 2 Diabetes in Non-Human Primates – Stephen V. Angeloni and Barbara Caleen Hansen
8 Effects of Genetic Alterations of Glut4 on Insulin Sensitivity – Naira Gorovits et al.
9 Insulin Signaling Pathway and GLUT4-mediated Glucose Transport in the Insulin Resistant Muscle – Daniel Konrad et al.
10 Which Genes are Important in the Development of Type 2 Diabetes? – G.R. Collier et al.
11 Leptin and Insulin Resistance in Rodent Models – Kevin L. Stark
12 Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance – E.W. Kraegen et al.
13 D-chiro-inositol and Insulin Resistance: An Allosteric Point of View – Joseph Larner
14 Glucagon-like Peptide-1, Exendin and Insulin Sensitivity – Andrew A. Young
15 Insulin Resistance and the Autonomic Nervous System – L. Penicaud et al.
16 Hypothalamic Role in the Insulin Resistance Syndrome – Anthony H. Cincotta
17 Insulin Resistance – Emerging Therapies for Affected Sites – Julie S. Moyers and José F. Caro

18 Effect of Age on the Emergence of Insulin Resistance – Nir Barzilai and Ilan Gabriely
19 Postnatal and Adult Insulin Sensitivity and Metabolism in Progeny of Nutritionally Compromised Mothers – Clive J. Petry, Susan E. Ozanne and C. Nicholas Hales

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Tags: Eleazar Shafrir, Barbara Hansen, Insulin Resistance, Insulin Resistance